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dc.contributor.author
Syme, Robert A.
dc.contributor.author
Tan, Kar-Chun
dc.contributor.author
Rybak, Kasia
dc.contributor.author
Friesen, Timothy L.
dc.contributor.author
McDonald, Bruce A.
dc.contributor.author
Oliver, Richard P.
dc.contributor.author
Hane, James K.
dc.date.accessioned
2018-11-22T17:50:27Z
dc.date.available
2018-11-09T05:02:49Z
dc.date.available
2018-11-22T17:50:27Z
dc.date.issued
2018-09-01
dc.identifier.issn
1759-6653
dc.identifier.other
10.1093/gbe/evy192
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/302229
dc.identifier.doi
10.3929/ethz-b-000302229
dc.description.abstract
We report a fungal pan-genome study involving Parastagonospora spp., including 21 isolates of the wheat (Triticum aestivum) pathogen Parastagonospora nodorum, 10 of the grass-infecting Parastagonospora avenae, and 2 of a closely related undefined sister species. We observed substantial variation in the distribution of polymorphisms across the pan-genome, including repeat-induced point mutations, diversifying selection and gene gains and losses. We also discovered chromosome-scale inter and intraspecific presence/absence variation of some sequences, suggesting the occurrence of one or more accessory chromosomes or regions that may play a role in host–pathogen interactions. The presence of known pathogenicity effector loci SnToxA, SnTox1, and SnTox3 varied substantially among isolates. Three P. nodorum isolates lacked functional versions for all three loci, whereas three P. avenae isolates carried one or both of the SnTox1 and SnTox3 genes, indicating previously unrecognized potential for discovering additional effectors in the P. nodorum-wheat pathosystem. We utilized the pan-genomic comparative analysis to improve the prediction of pathogenicity effector candidates, recovering the three confirmed effectors among our top-ranked candidates. We propose applying this pan-genomic approach to identify the effector repertoire involved in other host–microbe interactions involving necrotrophic pathogens in the Pezizomycotina.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Oxford University Press
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Parastagonospora nodorum
en_US
dc.subject
Pan-genome
en_US
dc.subject
plant pathogen
en_US
dc.subject
crop disease
en_US
dc.subject
host-microbe interactions
en_US
dc.title
Pan-Parastagonospora Comparative Genome Analysis-Effector Prediction and Genome Evolution
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2018-09-04
ethz.journal.title
Genome Biology and Evolution
ethz.journal.volume
10
en_US
ethz.journal.issue
9
en_US
ethz.journal.abbreviated
Genome biol. evol.
ethz.pages.start
2443
en_US
ethz.pages.end
2457
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.publication.place
Oxford
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02350 - Dep. Umweltsystemwissenschaften / Dep. of Environmental Systems Science::02720 - Institut für Integrative Biologie / Institute of Integrative Biology::03516 - McDonald, Bruce / McDonald, Bruce
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02350 - Dep. Umweltsystemwissenschaften / Dep. of Environmental Systems Science::02720 - Institut für Integrative Biologie / Institute of Integrative Biology::03516 - McDonald, Bruce / McDonald, Bruce
ethz.date.deposited
2018-11-09T05:02:53Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2018-11-22T17:50:46Z
ethz.rosetta.lastUpdated
2019-01-03T09:39:39Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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