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dc.contributor.author
Schuster-Amft, Corina
dc.contributor.author
Eng, Kynan
dc.contributor.author
Suica, Zorica
dc.contributor.author
Thaler, Irène
dc.contributor.author
Signer, Sandra
dc.contributor.author
Lehmann, Isabelle
dc.contributor.author
Schmid, Ludwig
dc.contributor.author
McCaskey, Michael A.
dc.contributor.author
Hawkins, Miura
dc.contributor.author
Verra, Martin L.
dc.contributor.author
Kiper, Daniel
dc.date.accessioned
2018-11-14T16:02:57Z
dc.date.available
2018-11-09T05:57:42Z
dc.date.available
2018-11-14T16:02:57Z
dc.date.issued
2018-10-24
dc.identifier.issn
1932-6203
dc.identifier.other
10.1371/journal.pone.0204455
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/302524
dc.identifier.doi
10.3929/ethz-b-000302524
dc.description.abstract
Background: Virtual reality-based training has found increasing use in neurorehabilitation to improve upper limb training and facilitate motor recovery. Objective: The aim of this study was to directly compare virtual reality-based training with conventional therapy. Methods: In a multi-center, parallel-group randomized controlled trial, patients at least 6 months after stroke onset were allocated either to an experimental group (virtual reality-based training) or a control group receiving conventional therapy (16x45 minutes within 4 weeks). The virtual reality-based training system replicated patients´ upper limb movements in real-time to manipulate virtual objects. Blinded assessors tested patients twice before, once during, and twice after the intervention up to 2-month follow-up for dexterity (primary outcome: Box and Block Test), bimanual upper limb function (Chedoke-McMaster Arm and Hand Activity Inventory), and subjective perceived changes (Stroke Impact Scale). Results: 54 eligible patients (70 screened) participated (15 females, mean age 61.3 years, range 20–81 years, time since stroke 3.0±SD 3 years). 22 patients were allocated to the experimental group and 32 to the control group (3 drop-outs). Patients in the experimental and control group improved: Box and Block Test mean 21.5±SD 16 baseline to mean 24.1±SD 17 follow-up; Chedoke-McMaster Arm and Hand Activity Inventory mean 66.0±SD 21 baseline to mean 70.2±SD 19 follow-up. An intention-to-treat analysis found no between-group differences. Conclusions: Patients in the experimental and control group showed similar effects, with most improvements occurring in the first two weeks and persisting until the end of the two-month follow-up period. The study population had moderate to severely impaired motor function at entry (Box and Block Test mean 21.5±SD 16). Patients, who were less impaired (Box and Block Test range 18 to 72) showed higher improvements in favor of the experimental group. This result could suggest that virtual reality-based training might be more applicable for such patients than for more severely impaired patients.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
PLOS
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
Effect of a four-week virtual reality-based training versus conventional therapy on upper limb motor function after stroke
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
ethz.title.subtitle
A multicenter parallel group randomized trial
en_US
ethz.journal.title
PLoS ONE
ethz.journal.volume
13
en_US
ethz.journal.issue
10
en_US
ethz.journal.abbreviated
PLoS ONE
ethz.pages.start
e0204455
en_US
ethz.size
19 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
San Francisco, CA
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02140 - Dep. Inf.technologie und Elektrotechnik / Dep. of Inform.Technol. Electrical Eng.::02533 - Institut für Neuroinformatik / Institute of Neuroinformatics
ethz.date.deposited
2018-11-09T05:57:46Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2018-11-14T16:03:34Z
ethz.rosetta.lastUpdated
2024-02-02T06:36:24Z
ethz.rosetta.versionExported
true
ethz.COinS
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