The Role of Recombination for the Coevolutionary Dynamics of HIV and the Immune Response
dc.contributor.author
Mostowy, Rafal
dc.contributor.author
Kouyos, Roger D.
dc.contributor.author
Fouchet, David
dc.contributor.author
Bonhoeffer, Sebastian
dc.date.accessioned
2018-08-09T13:22:07Z
dc.date.available
2017-06-09T09:33:09Z
dc.date.available
2018-08-09T13:22:07Z
dc.date.issued
2011-02-18
dc.identifier.issn
1932-6203
dc.identifier.other
10.1371/journal.pone.0016052
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/30521
dc.identifier.doi
10.3929/ethz-b-000030521
dc.description.abstract
The evolutionary implications of recombination in HIV remain not fully understood. A plausible effect could be an enhancement of immune escape from cytotoxic T lymphocytes (CTLs). In order to test this hypothesis, we constructed a population dynamic model of immune escape in HIV and examined the viral-immune dynamics with and without recombination. Our model shows that recombination (i) increases the genetic diversity of the viral population, (ii) accelerates the emergence of escape mutations with and without compensatory mutations, and (iii) accelerates the acquisition of immune escape mutations in the early stage of viral infection. We see a particularly strong impact of recombination in systems with broad, non-immunodominant CTL responses. Overall, our study argues for the importance of recombination in HIV in allowing the virus to adapt to changing selective pressures as imposed by the immune system and shows that the effect of recombination depends on the immunodominance pattern of effector T cell responses.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
PLOS
dc.rights.uri
http://creativecommons.org/licenses/by/3.0/
dc.title
The Role of Recombination for the Coevolutionary Dynamics of HIV and the Immune Response
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 3.0 Unported
ethz.journal.title
PLoS ONE
ethz.journal.volume
6
en_US
ethz.journal.issue
2
en_US
ethz.journal.abbreviated
PLoS ONE
ethz.pages.start
e16052
en_US
ethz.size
10 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.publication.place
San Francisco, CA
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02350 - Dep. Umweltsystemwissenschaften / Dep. of Environmental Systems Science::02720 - Institut für Integrative Biologie / Institute of Integrative Biology::03584 - Bonhoeffer, Sebastian / Bonhoeffer, Sebastian
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02350 - Dep. Umweltsystemwissenschaften / Dep. of Environmental Systems Science::02720 - Institut für Integrative Biologie / Institute of Integrative Biology::03584 - Bonhoeffer, Sebastian / Bonhoeffer, Sebastian
ethz.date.deposited
2017-06-09T09:33:38Z
ethz.source
ECIT
ethz.identifier.importid
imp59364dab9c16022032
ethz.ecitpid
pub:50700
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-18T11:07:15Z
ethz.rosetta.lastUpdated
2024-02-02T05:38:33Z
ethz.rosetta.versionExported
true
ethz.COinS
ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.atitle=The%20Role%20of%20Recombination%20for%20the%20Coevolutionary%20Dynamics%20of%20HIV%20and%20the%20Immune%20Response&rft.jtitle=PLoS%20ONE&rft.date=2011-02-18&rft.volume=6&rft.issue=2&rft.spage=e16052&rft.issn=1932-6203&rft.au=Mostowy,%20Rafal&Kouyos,%20Roger%20D.&Fouchet,%20David&Bonhoeffer,%20Sebastian&rft.genre=article&rft_id=info:doi/10.1371/journal.pone.0016052&
Files in this item
Publication type
-
Journal Article [133598]