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dc.contributor.author
Kammerer, Tobias
dc.contributor.author
Faihs, Valentina
dc.contributor.author
Hulde, Nikolai
dc.contributor.author
Bayer, Andreas
dc.contributor.author
Hübner, Max
dc.contributor.author
Brettner, Florian
dc.contributor.author
Karlen, Walter
dc.contributor.author
Kröpfl, Julia M.
dc.contributor.author
Rehm, Markus
dc.contributor.author
Spengler, Christina
dc.contributor.author
Schäfer, Simon T.
dc.date.accessioned
2018-11-26T07:51:45Z
dc.date.available
2018-11-25T22:04:23Z
dc.date.available
2018-11-26T07:51:45Z
dc.date.issued
2018-11-19
dc.identifier.other
10.1186/s40557-018-0276-2
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/305932
dc.identifier.doi
10.3929/ethz-b-000305932
dc.description.abstract
Objective Normobaric (NH) and hypobaric hypoxia (HH) are associated with acute mountain sickness (AMS) and cognitive dysfunction. Only few variables, like heart-rate-variability, are correlated with AMS. However, prediction of AMS remains difficult. We therefore designed an expedition-study with healthy volunteers in NH/HH to investigate additional non-invasive hemodynamic variables associated with AMS. Methods Eleven healthy subjects were examined in NH (FiO2 13.1%; equivalent of 3.883 m a.s.l; duration 4 h) and HH (3.883 m a.s.l.; duration 24 h) before and after an exercise of 120 min. Changes in parameters of electrical cardiometry (cardiac index (CI), left-ventricular ejection time (LVET), stroke volume (SV), index of contractility (ICON)), near-infrared spectroscopy (cerebral oxygenation, rScO2), Lake-Louise-Score (LLS) and cognitive function tests were assessed. One-Way-ANOVA, Wilcoxon matched-pairs test, Spearman’s-correlation-analysis and Student’s t-test were performed. Results HH increased heart rate (HR), mean arterial pressure (MAP) and CI and decreased LVET, SV and ICON, whereas NH increased HR and decreased LVET. In both NH and HH cerebral oxygenation decreased and LLS increased significantly. After 24 h in HH, 6 of 11 subjects (54.6%) developed AMS. LLS remained increased until 24 h in HH, whereas cognitive function remained unaltered. In HH, HR and LLS were inversely correlated (r = − 0.692; p < 0.05). More importantly, the rScO2-decrease after exercise in NH significantly correlated with LLS after 24 h in HH (r = − 0.971; p < 0.01) and rScO2 correlated significantly with HR (r = 0.802; p < 0.01), CI (r = 0.682; p < 0.05) and SV (r = 0.709; p < 0.05) after exercise in HH. Conclusions Both acute NH and HH altered hemodynamic and cerebral oxygenation and induced AMS. Subjects, who adapted their CI had higher rScO2 and lower LLS. Furthermore, rScO2 after exercise under normobaric conditions was associated with AMS at high altitudes.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
BioMed Central
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Acute mountain sickness
en_US
dc.subject
Cerebral oxygenation
en_US
dc.subject
Near-infrared spectroscopy
en_US
dc.subject
Normobaric hypoxia
en_US
dc.subject
Hypobaric hypoxia
en_US
dc.subject
Cognitive dysfunction
en_US
dc.title
Changes of hemodynamic and cerebral oxygenation after exercise in normobaric and hypobaric hypoxia: associations with acute mountain sickness
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
ethz.journal.title
Annals of Occupational and Environmental Medicine
ethz.journal.volume
30
en_US
ethz.pages.start
66
en_US
ethz.size
7 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.scopus
ethz.publication.place
London
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::09533 - Karlen, Walter (SNF-Förderprofessur) / Karlen, Walter (SNF-Förderprofessur)
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02535 - Institut für Bewegungswiss. und Sport / Institut of Human Movement Sc. and Sport::08691 - Spengler, Christina (Tit.-Prof.)
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02535 - Institut für Bewegungswiss. und Sport / Institut of Human Movement Sc. and Sport::08691 - Spengler, Christina (Tit.-Prof.)
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::09533 - Karlen, Walter (SNF-Förderprofessur) / Karlen, Walter (SNF-Förderprofessur)
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02535 - Institut für Bewegungswiss. und Sport / Institut of Human Movement Sc. and Sport::08691 - Spengler, Christina (Tit.-Prof.)
ethz.date.deposited
2018-11-25T22:04:33Z
ethz.source
FORM
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2018-11-26T07:52:03Z
ethz.rosetta.lastUpdated
2019-01-03T09:40:58Z
ethz.rosetta.versionExported
true
ethz.COinS
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