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dc.contributor.author
Huang, Ziqiang
dc.contributor.author
Khaled, Houda G.
dc.contributor.author
Kirschmann, Moritz
dc.contributor.author
Gobes, Sharon M.H.
dc.contributor.author
Hahnloser, Richard H.R.
dc.date.accessioned
2018-12-04T18:05:29Z
dc.date.available
2018-12-01T05:44:02Z
dc.date.available
2018-12-04T18:05:29Z
dc.date.issued
2018-10-25
dc.identifier.other
10.7554/eLife.37571
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/307896
dc.identifier.doi
10.3929/ethz-b-000307896
dc.description.abstract
Excitatory and inhibitory synapses are the brain’s most abundant synapse types. However, little is known about their formation during critical periods of motor skill learning, when sensory experience defines a motor target that animals strive to imitate. In songbirds, we find that exposure to tutor song leads to elimination of excitatory synapses in HVC (used here as a proper name), a key song generating brain area. A similar pruning is associated with song maturation, because juvenile birds have fewer excitatory synapses, the better their song imitations. In contrast, tutoring is associated with rapid insertion of inhibitory synapses, but the tutoring-induced structural imbalance between excitation and inhibition is eliminated during subsequent song maturation. Our work suggests that sensory exposure triggers the developmental onset of goal-specific motor circuits by increasing the relative strength of inhibition and it suggests a synapse-elimination model of song memorization.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
eLife Sciences Publications
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
Excitatory and inhibitory synapse reorganization immediately after critical sensory experience in a vocal learner
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
ethz.journal.title
eLife
ethz.journal.volume
7
en_US
ethz.pages.start
e37571
en_US
ethz.size
23 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.grant
Vocal tuning and sequencing in songbirds and in humans
en_US
ethz.grant
Songbirds as model for speech acquisition in humans
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Cambridge
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02140 - Dep. Inf.technologie und Elektrotechnik / Dep. of Inform.Technol. Electrical Eng.::02533 - Institut für Neuroinformatik / Institute of Neuroinformatics::03774 - Hahnloser, Richard H.R. / Hahnloser, Richard H.R.
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02140 - Dep. Inf.technologie und Elektrotechnik / Dep. of Inform.Technol. Electrical Eng.::02533 - Institut für Neuroinformatik / Institute of Neuroinformatics
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02140 - Dep. Inf.technologie und Elektrotechnik / Dep. of Inform.Technol. Electrical Eng.::02533 - Institut für Neuroinformatik / Institute of Neuroinformatics::03774 - Hahnloser, Richard H.R. / Hahnloser, Richard H.R.
ethz.grant.agreementno
156976
ethz.grant.agreementno
160663
ethz.grant.fundername
SNF
ethz.grant.fundername
SNF
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.program
Individuelle Kurzaufenthalte
ethz.grant.program
ethz.date.deposited
2018-12-01T05:44:05Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2018-12-04T18:05:44Z
ethz.rosetta.lastUpdated
2019-02-03T12:01:26Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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