Show simple item record

dc.contributor.author
Brites, Daniela
dc.contributor.author
Loiseau, Chloé
dc.contributor.author
Menardo, Fabrizio
dc.contributor.author
Borrell, Sonia
dc.contributor.author
Boniotti, Maria B.
dc.contributor.author
Warren, Robin
dc.contributor.author
Dippenaar, Anzaan
dc.contributor.author
Parsons, Sven D.C.
dc.contributor.author
Beisel, Christian
dc.contributor.author
Behr, Marcel A.
dc.contributor.author
Fyfe, Janet A.
dc.contributor.author
Coscolla, Mireia
dc.contributor.author
Gagneux, Sebastien
dc.date.accessioned
2018-12-12T15:55:14Z
dc.date.available
2018-12-06T05:54:49Z
dc.date.available
2018-12-12T15:55:14Z
dc.date.issued
2018-11
dc.identifier.issn
1664-302X
dc.identifier.other
10.3389/fmicb.2018.02820
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/309080
dc.identifier.doi
10.3929/ethz-b-000309080
dc.description.abstract
Tuberculosis (TB) affects humans and other animals and is caused by bacteria from the Mycobacterium tuberculosis complex (MTBC). Previous studies have shown that there are at least nine members of the MTBC infecting animals other than humans; these have also been referred to as ecotypes. However, the ecology and the evolution of these animal-adapted MTBC ecotypes are poorly understood. Here we screened 12,886 publicly available MTBC genomes and newly sequenced 17 animal-adapted MTBC strains, gathering a total of 529 genomes of animal-adapted MTBC strains. Phylogenomic and comparative analyses confirm that the animal-adapted MTBC members are paraphyletic with some members more closely related to the human-adapted Mycobacterium africanum Lineage 6 than to other animal-adapted strains. Furthermore, we identified four main animal-adapted MTBC clades that might correspond to four main host shifts; two of these clades are hypothesized to reflect independent cattle domestication events. Contrary to what would be expected from an obligate pathogen, MTBC nucleotide diversity was not positively correlated with host phylogenetic distances, suggesting that host tropism in the animal-adapted MTBC seems to be driven by contact rates and demographic aspects of the host population rather by than host relatedness. By combining phylogenomics with ecological data, we propose an evolutionary scenario in which the ancestor of Lineage 6 and all animal-adapted MTBC ecotypes was a generalist pathogen that subsequently adapted to different host species. This study provides a new phylogenetic framework to better understand the evolution of the different ecotypes of the MTBC and guide future work aimed at elucidating the molecular mechanisms underlying host range.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Fontiers Research Foundation
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
host–pathogen interactions
en_US
dc.subject
specificity
en_US
dc.subject
host range
en_US
dc.subject
genetic diversity
en_US
dc.subject
whole-genome sequencing
en_US
dc.title
A New Phylogenetic Framework for the Animal-Adapted Mycobacterium tuberculosis Complex
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2018-11-27
ethz.journal.title
Frontiers in Microbiology
ethz.journal.volume
9
en_US
ethz.journal.abbreviated
Front. microbiol.
ethz.pages.start
2820
en_US
ethz.size
14 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Lausanne
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2018-12-06T05:54:51Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2018-12-12T15:55:39Z
ethz.rosetta.lastUpdated
2018-12-12T15:55:39Z
ethz.rosetta.versionExported
true
ethz.COinS
ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.atitle=A%20New%20Phylogenetic%20Framework%20for%20the%20Animal-Adapted%20Mycobacterium%20tuberculosis%20Complex&rft.jtitle=Frontiers%20in%20Microbiology&rft.date=2018-11&rft.volume=9&rft.spage=2820&rft.issn=1664-302X&rft.au=Brites,%20Daniela&Loiseau,%20Chlo%C3%A9&Menardo,%20Fabrizio&Borrell,%20Sonia&Boniotti,%20Maria%20B.&rft.genre=article&
 Search via SFX

Files in this item

Thumbnail

Publication type

Show simple item record