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dc.contributor.author
Walker, Tara L.
dc.contributor.author
Schallenberg, Sonja
dc.contributor.author
Rund, Nicole
dc.contributor.author
Grönnert, Lisa
dc.contributor.author
Rust, Ruslan
dc.contributor.author
Kretschmer, Karsten
dc.contributor.author
Kempermann, Gerd
dc.date.accessioned
2019-01-03T11:23:03Z
dc.date.available
2018-12-22T10:38:43Z
dc.date.available
2019-01-03T11:23:03Z
dc.date.issued
2018-12-11
dc.identifier.other
10.3389/fimmu.2018.02856
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/313177
dc.identifier.doi
10.3929/ethz-b-000313177
dc.description.abstract
Cross-talk between the peripheral immune system and the central nervous system is important for physiological brain health. T cells are required to maintain normal baseline levels of neural precursor proliferation in the hippocampus of adult mice. We show here that neither T cells, B cells, natural killer cells nor natural killer T cells are required for the increase in hippocampal precursor proliferation that occurs in response to physical exercise. In addition, we demonstrate that a subpopulation of T cells, regulatory T cells, is not involved in maintaining baseline levels of neural precursor proliferation. Even when applied at supraphysiological numbers, populations of both naive and stimulated lymphocytes had no effect on hippocampal precursor proliferation in vitro. In addition, physical activity had no effect on peripheral immune cells in terms of distribution in the bone marrow, lymph nodes or spleen, activation state or chemokine receptor (CXCR4 and CCR9) expression. Together these results suggest that lymphocytes are not involved in translating the peripheral effects of exercise to the neurogenic niche in the hippocampus and further support the idea that the exercise-induced regulation of adult neurogenesis is mechanistically distinct from its baseline control.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Frontiers Research Foundation
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
T cell
en_US
dc.subject
Regulatory T cell
en_US
dc.subject
Adult neurogenesis
en_US
dc.subject
Neural precursor cell
en_US
dc.subject
Dentate gyrus
en_US
dc.subject
Hippocampus
en_US
dc.subject
Physical activity
en_US
dc.title
T Lymphocytes Contribute to the Control of Baseline Neural Precursor Cell Proliferation but Not the Exercise-Induced Up-Regulation of Adult Hippocampal Neurogenesis
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
ethz.journal.title
Frontiers in Immunology
ethz.journal.volume
9
en_US
ethz.pages.start
2856
en_US
ethz.size
14 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.publication.place
Lausanne
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2018-12-22T10:38:44Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2019-01-03T11:23:10Z
ethz.rosetta.lastUpdated
2020-02-15T16:29:09Z
ethz.rosetta.versionExported
true
ethz.COinS
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