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dc.contributor.author
Sarker, Gitalee
dc.contributor.author
Peleg-Raibstein, Daria
dc.date.accessioned
2019-01-04T16:48:12Z
dc.date.available
2018-12-30T03:42:26Z
dc.date.available
2019-01-04T16:48:12Z
dc.date.issued
2018-12-20
dc.identifier.other
10.3390/nu11010007
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/313379
dc.identifier.doi
10.3929/ethz-b-000313379
dc.description.abstract
Ample evidence from epidemiological studies has linked maternal obesity with metabolic disorders such as obesity, cardiovascular disease, and diabetes in the next generation. Recently, it was also shown that maternal obesity has long-term effects on the progeny’s central nervous system. However, very little is known regarding how maternal overnutrition may affect, in particular, the cognitive abilities of the offspring. We reported that first-generation offspring exposed to a maternal high-fat diet (MHFD) displayed age-dependent cognitive deficits. These deficits were associated with attenuations of amino acid levels in the medial prefrontal cortex and the hippocampus regions of MHFD offspring. Here, we tested the hypothesis that MHFD in mice may induce long-term cognitive impairments and neurochemical dysfunctions in the second and third generations. We found that MHFD led to cognitive disabilities and an altered response to a noncompetitive receptor antagonist of the N-Methyl-D-aspartic acid (NMDA) receptor in adult MHFD offspring in both second and third generations in a sex-specific manner. Our results suggest that maternal overnutrition leads to an increased risk of developing obesity in subsequent generations as well as to cognitive impairments, affecting learning and memory processes in adulthood. Furthermore, MHFD exposure may facilitate pathological brain aging which is not a consequence of obesity. Our findings shed light on the long-term effects of maternal overnutrition on the development of the central nervous system and the underlying mechanisms which these traits relate to disease predisposition.
en_US
dc.format
application/pdf
dc.language.iso
en
en_US
dc.publisher
MDPI
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
cognition
en_US
dc.subject
maternal
en_US
dc.subject
mice
en_US
dc.subject
amino acids
en_US
dc.subject
overnutrition
en_US
dc.subject
obesity
en_US
dc.title
Maternal Overnutrition Induces Long-Term Cognitive Deficits across Several Generations
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
ethz.journal.title
Nutrients
ethz.journal.volume
11
en_US
ethz.journal.issue
1
en_US
ethz.pages.start
7
en_US
ethz.size
19 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Basel
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2018-12-30T03:42:27Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2019-01-04T16:48:22Z
ethz.rosetta.lastUpdated
2021-02-15T03:13:21Z
ethz.rosetta.versionExported
true
ethz.COinS
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