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dc.contributor.author
Qi, Weihong
dc.contributor.author
Cascarano, Maria C.
dc.contributor.author
Schlapbach, Ralph
dc.contributor.author
Katharios, Pantelis
dc.contributor.author
Vaughan, Lloyd
dc.contributor.author
Seth-Smith, Helena M.B.
dc.date.accessioned
2019-01-28T16:04:40Z
dc.date.available
2019-01-23T08:19:08Z
dc.date.available
2019-01-28T16:04:40Z
dc.date.issued
2018-06
dc.identifier.issn
1759-6653
dc.identifier.other
10.1093/gbe/evy092
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/318755
dc.identifier.doi
10.3929/ethz-b-000318755
dc.description.abstract
Endozoicomonas bacteria are generally beneficial symbionts of diverse marine invertebrates including reef-building corals, sponges, sea squirts, sea slugs, molluscs, and Bryozoans. In contrast, the recently reported Ca. Endozoicomonas cretensis was identified as a vertebrate pathogen, causing epitheliocystis in fish larvae resulting in massive mortality. Here, we described the Ca. E. cretensis draft genome, currently undergoing genome decay as evidenced by massive insertion sequence (IS element) expansion and pseudogene formation. Many of the insertion sequences are also predicted to carry outward-directed promoters, implying that they may be able to modulate the expression of neighbouring coding sequences (CDSs). Comparative genomic analysis has revealed many Ca. E. cretensis-specific CDSs, phage integration and novel gene families. Potential virulence related CDSs and machineries were identified in the genome, including secretion systems and related effector proteins, and systems related to biofilm formation and directed cell movement. Mucin degradation would be of importance to a fish pathogen, and many candidate CDSs associated with this pathway have been identified. The genome may reflect a bacterium in the process of changing niche from symbiont to pathogen, through expansion of virulence genes and some loss of metabolic capacity.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Oxford University Press
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc/4.0/
dc.subject
host–pathogen
en_US
dc.subject
resistance
en_US
dc.subject
virulence
en_US
dc.subject
genome degradation
en_US
dc.subject
genome decay
en_US
dc.subject
mobile elements
en_US
dc.title
Ca. Endozoicomonas cretensis: A Novel Fish Pathogen Characterized by Genome Plasticity
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial 4.0 International
dc.date.published
2018-05-03
ethz.journal.title
Genome Biology and Evolution
ethz.journal.volume
10
en_US
ethz.journal.issue
6
en_US
ethz.journal.abbreviated
Genome biol. evol.
ethz.pages.start
1363
en_US
ethz.pages.end
1374
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.publication.place
Oxford
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00003 - Schulleitung und Dienste::00022 - Bereich VP Forschung & Wirtschaftsbez. / Domain VP Research & Corporate Relations::02207 - Functional Genomics Center Zürich / Functional Genomics Center Zürich
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00003 - Schulleitung und Dienste::00022 - Bereich VP Forschung & Wirtschaftsbez. / Domain VP Research & Corporate Relations::02207 - Functional Genomics Center Zürich / Functional Genomics Center Zürich
en_US
ethz.date.deposited
2019-01-23T08:19:15Z
ethz.source
FORM
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2019-01-28T16:05:08Z
ethz.rosetta.lastUpdated
2019-01-28T16:05:08Z
ethz.rosetta.versionExported
true
ethz.COinS
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