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dc.contributor.author
Boos, Julia A.
dc.contributor.author
Modena, Mario M.
dc.contributor.author
Misun, Patrick M.
dc.contributor.author
Renggli, Kasper
dc.contributor.author
Frey, Olivier
dc.contributor.author
Hierlemann, Andreas
dc.date.accessioned
2020-02-19T14:13:12Z
dc.date.available
2019-01-31T09:42:25Z
dc.date.available
2019-01-31T12:57:00Z
dc.date.available
2020-02-19T14:13:12Z
dc.date.issued
2018
dc.identifier.isbn
978-0-578-40530-8
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/321794
dc.description.abstract
Assessing the toxicity of prodrugs still constitutes a major challenge in current cell-based assays. Here, we present a microfluidic platform to test the toxic effects of liver-activated prodrugs on early embryonic development. Embryoid bodies (EBs) and human liver microtissues (hLiMTs, InSphero AG) were combined in a hanging-drop network (HDN, [1]) which features an ideal environment for the formation and cultivation of 3D spherical microtissues. By tilting the device, gravity-driven flow through the network was induced and allowed for continuous compound-tissue interaction. As a proof of concept, the prodrug cyclophosphamide (CP) was investigated, the metabolites of which are known to be teratogenic.
en_US
dc.language.iso
en
en_US
dc.publisher
Chemical and Biological Microsystems Society
en_US
dc.subject
Microfluidics
en_US
dc.subject
Hanging drops
en_US
dc.subject
3D microtissues
en_US
dc.subject
Embryonic stem cell tests
en_US
dc.subject
Embryoid bodies
en_US
dc.title
Microfluidic multi-organ platform to study the effect of prodrugs on early embryonic development
en_US
dc.type
Other Conference Item
ethz.book.title
22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2018)
en_US
ethz.pages.start
291
en_US
ethz.pages.end
292
en_US
ethz.event
22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2018)
en_US
ethz.event.location
Koahsiung, Taiwan
en_US
ethz.event.date
November 11-15, 2018
en_US
ethz.notes
Extended abstract. Conference lecture on November 14, 2018.
ethz.publication.place
San Diego, CA
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02060 - Dep. Biosysteme / Dep. of Biosystems Science and Eng.::03684 - Hierlemann, Andreas / Hierlemann, Andreas
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02060 - Dep. Biosysteme / Dep. of Biosystems Science and Eng.::03684 - Hierlemann, Andreas / Hierlemann, Andreas
en_US
ethz.date.deposited
2019-01-31T09:42:27Z
ethz.source
FORM
ethz.eth
yes
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.installDate
2020-02-19T14:13:24Z
ethz.rosetta.lastUpdated
2022-03-29T01:01:53Z
ethz.rosetta.versionExported
true
ethz.COinS
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