Evolutionary repurposing of a sulfatase: A new Michaelis complex leads to efficient transition state charge offset

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Author
Miton, Charlotte M.
Jonas, Stefanie
Fischer, Gerhard
Duarte, Fernanda
Mohamed, Mark F.
van Loo, Bert
Kintses, Bálint
Kamerlin, Shina C.L.
Tokuriki, Nobuhiko
Hyvonen, Marko
Hollfelder, Florian
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Date
2018-07-31
Type
  • Journal Article
Publication status
published
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Journal / series
Proceedings of the National Academy of Sciences of the United States of America
Volume
115(31)
Pages / Article No.
E7293 - E7302
Publisher
National Academy of Sciences
Subject
catalytic promiscuity; directed evolution; linear free-energy relationship; phosphate transfer; enzyme-substrate complementarity
Organisational unit
09609 - Jonas, Stefanie / Jonas, Stefanie  
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