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dc.contributor.author
Kikkert, Sanne
dc.contributor.author
Mezue, Melvin
dc.contributor.author
O'Shea, Jacinta
dc.contributor.author
Henderson Slater, David
dc.contributor.author
Johansen-Berg, Heidi
dc.contributor.author
Tracey, Irene
dc.contributor.author
Makin, Tamar R.
dc.date.accessioned
2019-02-08T14:51:28Z
dc.date.available
2019-02-01T04:46:29Z
dc.date.available
2019-02-08T14:51:28Z
dc.date.issued
2019-01
dc.identifier.issn
0364-5134
dc.identifier.issn
1531-8249
dc.identifier.other
10.1002/ana.25371
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/322322
dc.identifier.doi
10.3929/ethz-b-000322322
dc.description.abstract
Objective Phantom limb pain (PLP) is notoriously difficult to treat, partly due to an incomplete understanding of PLP‐related disease mechanisms. Noninvasive brain stimulation (NIBS) is used to modulate plasticity in various neuropathological diseases, including chronic pain. Although NIBS can alleviate neuropathic pain (including PLP), both disease and treatment mechanisms remain tenuous. Insight into the mechanisms underlying both PLP and NIBS‐induced PLP relief is needed for future implementation of such treatment and generalization to related conditions. Methods We used a within‐participants, double‐blind, and sham‐controlled design to alleviate PLP via task‐concurrent NIBS over the primary sensorimotor missing hand cortex (S1/M1). To specifically influence missing hand signal processing, amputees performed phantom hand movements during anodal transcranial direct current stimulation. Brain activity was monitored using neuroimaging during and after NIBS. PLP ratings were obtained throughout the week after stimulation. Results A single session of intervention NIBS significantly relieved PLP, with effects lasting at least 1 week. PLP relief associated with reduced activity in the S1/M1 missing hand cortex after stimulation. Critically, PLP relief and reduced S1/M1 activity correlated with preceding activity changes during stimulation in the mid‐ and posterior insula and secondary somatosensory cortex (S2). Interpretation The observed correlation between PLP relief and decreased S1/M1 activity confirms our previous findings linking PLP with increased S1/M1 activity. Our results further highlight the driving role of the mid‐ and posterior insula, as well as S2, in modulating PLP. Lastly, our novel PLP intervention using task‐concurrent NIBS opens new avenues for developing treatment for PLP and related pain conditions. ANN NEUROL 2019;85:59–73.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Wiley
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
Neural basis of induced phantom limb pain relief
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2018-11-01
ethz.journal.title
Annals of Neurology
ethz.journal.volume
85
en_US
ethz.journal.issue
1
en_US
ethz.journal.abbreviated
Ann Neurol
ethz.pages.start
59
en_US
ethz.pages.end
73
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Hoboken
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2019-02-01T04:46:32Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2019-02-08T14:52:01Z
ethz.rosetta.lastUpdated
2019-02-08T14:52:01Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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