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dc.contributor.author
Hua, Jun
dc.contributor.author
Lee, SeungWook
dc.contributor.author
Blair, Nicholas I.S.
dc.contributor.author
Wyss, Michael
dc.contributor.author
Van Bergen, Jiri M.G.
dc.contributor.author
Schreiner, Simon J.
dc.contributor.author
Kagerer, Sonja M.
dc.contributor.author
Leh, Sandra E.
dc.contributor.author
Gietl, Anton F.
dc.contributor.author
Treyer, Valerie
dc.contributor.author
Buck, Alfred
dc.contributor.author
Nitsch, Roger M.
dc.contributor.author
Pruessmann, Klaas P.
dc.contributor.author
Lu, Hanzhang
dc.contributor.author
Van Zijl, Peter C.M.
dc.contributor.author
Albert, Marilyn
dc.contributor.author
Hock, Christoph
dc.contributor.author
Unschuld, Paul G.
dc.date.accessioned
2019-02-13T12:59:00Z
dc.date.available
2019-02-11T04:34:28Z
dc.date.available
2019-02-13T12:59:00Z
dc.date.issued
2019-04
dc.identifier.other
10.1016/j.neurobiolaging.2019.01.001
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/324092
dc.identifier.doi
10.3929/ethz-b-000324092
dc.description.abstract
The protracted accumulation of amyloid-β (Aβ) is a major pathologic hallmark of Alzheimer's disease and may trigger secondary pathological processes that include neurovascular damage. This study was aimed at investigating long-term effects of Aβ burden on cerebral blood volume of arterioles and pial arteries (CBVa), possibly present before manifestation of dementia. Aβ burden was assessed by 11C Pittsburgh compound-B positron emission tomography in 22 controls and 18 persons with mild cognitive impairment (MCI), [ages: 75(±6) years]. After 2 years, inflow-based vascular space occupancy at ultra-high field strength of 7-Tesla was administered for measuring CBVa, and neuropsychological testing for cognitive decline. Crushing gradients were incorporated during MR-imaging to suppress signals from fast-flowing blood in large arteries, and thereby sensitize inflow-based vascular space occupancy to CBVa in pial arteries and arterioles. CBVa was significantly elevated in MCI compared to cognitively normal controls and regional CBVa related to local Aβ deposition. For both MCI and controls, Aβ burden and follow-up CBVa in several brain regions synergistically predicted cognitive decline over 2 years. Orbitofrontal CBVa was positively associated with apolipoprotein E e4 carrier status. Increased CBVa may reflect long-term effects of region-specific pathology associated with Aβ deposition. Additional studies are needed to clarify the role of the arteriolar system and the potential of CBVa as a biomarker for Aβ-related vascular downstream pathology.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Elsevier
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
MRI
en_US
dc.subject
PET
en_US
dc.subject
CBV
en_US
dc.subject
7 Tesla
en_US
dc.subject
Imaging
en_US
dc.subject
Biomarker
en_US
dc.subject
Vascular
en_US
dc.subject
Perfusion
en_US
dc.subject
High field
en_US
dc.subject
Aging
en_US
dc.subject
Cerebral autoregulation
en_US
dc.subject
Alzheimer’s disease
en_US
dc.title
Increased cerebral blood volume in small arterial vessels is a correlate of amyloid-β–related cognitive decline
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2019-01-10
ethz.journal.title
Neurobiology of Aging
ethz.journal.volume
76
en_US
ethz.pages.start
181
en_US
ethz.pages.end
193
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Amsterdam
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2019-02-11T04:34:30Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2019-02-13T12:59:07Z
ethz.rosetta.lastUpdated
2019-02-13T12:59:07Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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