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dc.contributor.author
Hagenmuller, Florence
dc.contributor.author
Heekeren, Karsten
dc.contributor.author
Roser, Patrik
dc.contributor.author
Haker, Helene
dc.contributor.author
Theodoridou, Anastasia
dc.contributor.author
Walitza, Susanne
dc.contributor.author
Rössler, Wulf
dc.contributor.author
Kawohl, Wolfram
dc.date.accessioned
2019-02-28T12:29:41Z
dc.date.available
2019-02-27T11:36:27Z
dc.date.available
2019-02-28T12:29:41Z
dc.date.issued
2019-02-13
dc.identifier.issn
1664-0640
dc.identifier.other
10.3389/fpsyt.2019.00047
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/328061
dc.identifier.doi
10.3929/ethz-b-000328061
dc.description.abstract
Objective: Somatosensory evoked potentials (SEPs) enable the investigation of thalamocortical and early cortical processing. Previous studies reported alterations of SEPs in patients with schizophrenia as well as in individuals in the prodromal stage. Moreover, cannabis use as an environmental risk factor for the development of schizophrenia has been demonstrated to influence SEP parameters in individuals at risk to develop psychosis. The aim of this study was to explore the course of SEP changes and the impact of concomitant cannabis use in individuals at risk to develop psychosis who sought medical help. Methods: Median nerve SEPs including high-frequency oscillations (HFOs) superimposed on the primary cortical response (N20) were investigated using multichannel EEG in individuals (n = 54 at baseline) remaining at risk to develop psychosis at follow-up after 1 year (high-risk: n = 19; ultra-high-risk: n = 27) vs. subjects with conversion to psychosis (n = 8) and a healthy control group (n = 35). Longitudinal and cross-sectional analyses of SEP components as estimated by dipole source analysis were performed. Results: The longitudinal development of the N20 strength depended on cannabis use. In cannabis non-users, a greater decrease of N20 strengths over time was associated with more negative symptoms at baseline. At baseline, converters did not differ from subjects remaining at risk. At follow-up, converters showed increased low- and high-frequency activity than at-risk subjects and did not differ from controls. Conclusion: The results of this study lead to the suggestion that the deficits in early somatosensory processing in individuals at risk to develop psychosis may not represent a marker for a genetic risk for psychosis but rather reflect state-dependent factors such as negative symptoms. On the other hand, the transition to psychosis seems to represent an interstage between reduced sensory registration from the at-risk state and gating deficits in the chronic state.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Frontiers Research Foundation
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Somatosensory processing
en_US
dc.subject
SEP
en_US
dc.subject
Thalamus
en_US
dc.subject
Psychosis
en_US
dc.subject
at-risk
en_US
dc.subject
Transition
en_US
dc.subject
Cannabis use
en_US
dc.title
Early Somatosensory Processing Over Time in Individuals at Risk to Develop Psychosis
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
ethz.journal.title
Frontiers in Psychiatry
ethz.journal.volume
10
en_US
ethz.pages.start
47
en_US
ethz.size
13 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.publication.place
Lausanne
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02140 - Dep. Inf.technologie und Elektrotechnik / Dep. of Inform.Technol. Electrical Eng.::02631 - Institut für Biomedizinische Technik / Institute for Biomedical Engineering::03955 - Stephan, Klaas E. / Stephan, Klaas E.
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02140 - Dep. Inf.technologie und Elektrotechnik / Dep. of Inform.Technol. Electrical Eng.::02631 - Institut für Biomedizinische Technik / Institute for Biomedical Engineering::03955 - Stephan, Klaas E. / Stephan, Klaas E.
ethz.date.deposited
2019-02-27T11:36:28Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2019-02-28T12:29:52Z
ethz.rosetta.lastUpdated
2019-02-28T12:29:52Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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