Show simple item record

dc.contributor.author
Sesterhenn, Fabian
dc.contributor.author
Galloux, Marie
dc.contributor.author
Csepregi, Lucia
dc.contributor.author
Yang, Che
dc.contributor.author
Descamps, Delphyne
dc.contributor.author
Bonet, Jaume
dc.contributor.author
Friedensohn, Simon
dc.contributor.author
Gainza, Pablo
dc.contributor.author
Corthésy, Patricia
dc.contributor.author
Chen, Man
dc.contributor.author
Rosset, Stéphane
dc.contributor.author
Rameix-Welt, Marie-Anne
dc.contributor.author
Éléouët, Jean-Francois
dc.contributor.author
Reddy, Sai T.
dc.contributor.author
Graham, Barney S.
dc.contributor.author
Riffault, Sabine
dc.contributor.author
Correia, Bruno E.
dc.date.accessioned
2019-03-18T17:35:34Z
dc.date.available
2019-03-16T04:11:39Z
dc.date.available
2019-03-18T17:35:34Z
dc.date.issued
2019
dc.identifier.issn
1544-9173
dc.identifier.issn
1545-7885
dc.identifier.other
10.1371/journal.pbio.3000164
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/331744
dc.identifier.doi
10.3929/ethz-b-000331744
dc.description.abstract
Throughout the last several decades, vaccination has been key to prevent and eradicate infectious diseases. However, many pathogens (e.g., respiratory syncytial virus [RSV], influenza, dengue, and others) have resisted vaccine development efforts, largely because of the failure to induce potent antibody responses targeting conserved epitopes. Deep profiling of human B cells often reveals potent neutralizing antibodies that emerge from natural infection, but these specificities are generally subdominant (i.e., are present in low titers). A major challenge for next-generation vaccines is to overcome established immunodominance hierarchies and focus antibody responses on crucial neutralization epitopes. Here, we show that a computationally designed epitope-focused immunogen presenting a single RSV neutralization epitope elicits superior epitope-specific responses compared to the viral fusion protein. In addition, the epitope-focused immunogen efficiently boosts antibodies targeting the palivizumab epitope, resulting in enhanced neutralization. Overall, we show that epitope-focused immunogens can boost subdominant neutralizing antibody responses in vivo and reshape established antibody hierarchies.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Public Library of Science
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
Boosting subdominant neutralizing antibody responses with a computationally designed epitope-focused immunogen
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2019-02-21
ethz.journal.title
PLoS Biology
ethz.journal.volume
17
en_US
ethz.journal.issue
2
en_US
ethz.journal.abbreviated
PLoS biol.
ethz.pages.start
e3000164
en_US
ethz.size
27 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Lawrence, KS
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2019-03-16T04:11:44Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2019-03-18T17:35:52Z
ethz.rosetta.lastUpdated
2019-03-18T17:35:52Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.atitle=Boosting%20subdominant%20neutralizing%20antibody%20responses%20with%20a%20computationally%20designed%20epitope-focused%20immunogen&rft.jtitle=PLoS%20Biology&rft.date=2019&rft.volume=17&rft.issue=2&rft.spage=e3000164&rft.issn=1544-9173&1545-7885&rft.au=Sesterhenn,%20Fabian&Galloux,%20Marie&Csepregi,%20Lucia&Yang,%20Che&Descamps,%20Delphyne&rft.genre=article&
 Search via SFX

Files in this item

Thumbnail

Publication type

Show simple item record