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dc.contributor.author
Schättin, Alexandra
dc.contributor.author
Baier, Corinne
dc.contributor.author
Mai, Domenique
dc.contributor.author
Klamroth-Marganska, Verena
dc.contributor.author
Herter-Aeberli, Isabelle
dc.contributor.author
de Bruin, Eling D.
dc.date.accessioned
2019-03-21T09:47:47Z
dc.date.available
2019-03-21T04:11:39Z
dc.date.available
2019-03-21T09:47:47Z
dc.date.issued
2019
dc.identifier.issn
1471-2318
dc.identifier.other
10.1186/s12877-019-1084-4
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/332761
dc.identifier.doi
10.3929/ethz-b-000332761
dc.description.abstract
Background Older adults often suffer from age- and behavior-related brain changes affecting neuronal functioning and, therefore, cognitive and motor functions. The improvement of these functions might decrease falls and improve mobility. Previous studies indicate that video game-based physical exercise, so-called exergames, or omega-3 fatty acids (FAs) improve motor and cognitive functioning through brain adaptations. The aim of this study was to assess the effects of exergame training combined with fish oil supplementation on neuronal system levels in the brain and behavioral measurements in older adults. We hypothesized that the combination would differently affect these factors compared to the sole administration of exergame. Methods Fifty-eight participants were randomly assigned to one of two groups (N = 29 each group) in a parallel, double-blind, randomized controlled trial lasting 26 weeks. The experimental group received daily fish oil, whereas the control group received daily olive oil. After 16 weeks, both groups started with an exergame training. Measurements were performed pre, during, and post intervention. Primary outcomes were recruitment curves using transcranial magnetic stimulation and response-locked potentials using electroencephalography. Secondary outcomes included executive functions and gait parameters. Blood samples were taken to control for FAs. Results Forty-three individuals (mean age 69.4 ± 4.6 years) completed the study (Nexperimental = 22, Ncontrol = 21). The results showed no significant time × group interaction effects for any parameters. Blood samples demonstrated significant time × group interaction effects. Post-hoc tests showed a significant increase of omega-3 FAs (p < .001) and a significant decrease of omega-6 FAs (p < .001) for the experimental group. Conclusion The combination of exergame training and fish oil did not lead to additional beneficial effects. To trigger possible effects, future studies should carefully consider study design aspects; e.g. study duration, individual nutritional supplementation dose, omega-3 FAs supplementation composition, and placebo. Furthermore, studies should consider neuroimaging methods as these might be more sensitive to assess early brain adaptations. Thus, future studies should be aware of several aspects running a combinatory study that includes omega-3 FAs according to their expected effects.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
BioMed Central
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Nutritional supplementation
en_US
dc.subject
Omega-3 fatty acids
en_US
dc.subject
Physical exercise
en_US
dc.subject
Exergame
en_US
dc.subject
Brain function
en_US
dc.subject
Brain structure
en_US
dc.subject
Older adults
en_US
dc.subject
Aging
en_US
dc.title
Effects of exergame training combined with omega-3 fatty acids on the elderly brain: a randomized double-blind placebo-controlled trial
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2019-03-13
ethz.journal.title
BMC Geriatrics
ethz.journal.volume
19
en_US
ethz.journal.issue
1
en_US
ethz.journal.abbreviated
BMC geriatr.
ethz.pages.start
81
en_US
ethz.size
16 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
London
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2019-03-21T04:11:40Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2019-03-21T09:47:52Z
ethz.rosetta.lastUpdated
2019-03-21T09:47:52Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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