
Open access
Date
2019-03-27Type
- Journal Article
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Cited 7 times in
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Abstract
Determining atomic-level characteristics of molecules on two-dimensional surfaces is one of the fundamental challenges in chemistry. High-resolution nuclear magnetic resonance (NMR) could deliver rich structural information, but its application to two-dimensional materials has been prevented by intrinsically low sensitivity. Here we obtain high-resolution one- and two-dimensional 31P NMR spectra from as little as 160 picomoles of oligonucleotide functionalities deposited onto silicate glass and sapphire wafers. This is enabled by a factor >105 improvement in sensitivity compared to typical NMR approaches from combining dynamic nuclear polarization methods, multiple-echo acquisition, and optimized sample formulation. We demonstrate that, with this ultrahigh NMR sensitivity, 31P NMR can be used to observe DNA bound to miRNA, to sense conformational changes due to ion binding, and to follow photochemical degradation reactions. Show more
Permanent link
https://doi.org/10.3929/ethz-b-000336248Publication status
publishedExternal links
Journal / series
ACS Central ScienceVolume
Pages / Article No.
Publisher
American Chemical SocietyOrganisational unit
03872 - Copéret, Christophe / Copéret, Christophe
03760 - Hall, Jonathan / Hall, Jonathan
Funding
169612 - Chemical Approaches to Functionalize Human microRNAs (SNF)
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Citations
Cited null times in
Web of Science
Cited 7 times in
Scopus
ETH Bibliography
yes
Altmetrics