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dc.contributor.author
Boran, Ece
dc.contributor.author
Fedele, Tommaso
dc.contributor.author
Klaver, Peter
dc.contributor.author
Hilfiker, Peter
dc.contributor.author
Stieglitz, Lennart
dc.contributor.author
Grunwald, Thomas
dc.contributor.author
Sarnthein, Johannes
dc.date.accessioned
2019-04-08T08:02:08Z
dc.date.available
2019-04-06T01:23:18Z
dc.date.available
2019-04-08T08:02:08Z
dc.date.issued
2019-03-01
dc.identifier.issn
2375-2548
dc.identifier.other
10.1126/sciadv.aav3687
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/336597
dc.identifier.doi
10.3929/ethz-b-000336597
dc.description.abstract
The maintenance of items in working memory relies on persistent neural activity in a widespread network of brain areas. To investigate the influence of load on working memory, we asked human subjects to maintain sets of letters in memory while we recorded single neurons and intracranial encephalography (EEG) in the medial temporal lobe and scalp EEG. Along the periods of a trial, hippocampal neural firing differentiated between success and error trials during stimulus encoding, predicted workload during memory maintenance, and predicted the subjects’ behavior during retrieval. During maintenance, neuronal firing was synchronized with intracranial hippocampal EEG. On the network level, synchronization between hippocampal and scalp EEG in the theta-alpha frequency range showed workload dependent oscillatory coupling between hippocampus and cortex. Thus, we found that persistent neural activity in the hippocampus participated in working memory processing that is specific to memory maintenance, load sensitive and synchronized to the cortex.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
AAAS
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc/4.0/
dc.title
Persistent hippocampal neural firing and hippocampal-cortical coupling predict verbal working memory load
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial 4.0 International
dc.date.published
2019-03-27
ethz.journal.title
Science Advances
ethz.journal.volume
5
en_US
ethz.journal.issue
3
en_US
ethz.journal.abbreviated
Sci Adv
ethz.pages.start
eaav3687
en_US
ethz.size
15 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Washington, DC
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2019-04-06T01:23:20Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2019-04-08T08:02:25Z
ethz.rosetta.lastUpdated
2021-02-15T04:17:19Z
ethz.rosetta.versionExported
true
ethz.COinS
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