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dc.contributor.author
Aloisi, Claudia M.N.
dc.contributor.author
Sturla, Shana J.
dc.contributor.author
Gahlon, Hailey L.
dc.date.accessioned
2019-04-23T14:53:36Z
dc.date.available
2019-04-19T01:41:15Z
dc.date.available
2019-04-23T14:53:36Z
dc.date.issued
2019-04-07
dc.identifier.issn
1359-7345
dc.identifier.issn
1364-548X
dc.identifier.other
10.1039/c9cc00278b
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/338778
dc.identifier.doi
10.3929/ethz-b-000338778
dc.description.abstract
Detecting DNA adducts in cancer genes is important for understanding cancer etiology. This study reports a strategy to identify the mutagenic DNA adduct O6-methylguanine in K-Ras. The strategy involves selective replication past a synthetic primer when placed opposite O6-methylguanine. Future work can apply this approach to other cancer-relevant genes.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Royal Society of Chemistry
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/3.0/
dc.title
A gene-targeted polymerase-mediated strategy to identify O6 -methylguanine damage
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 3.0 Unported
dc.date.published
2019-03-06
ethz.journal.title
Chemical Communications
ethz.journal.volume
55
en_US
ethz.journal.issue
27
en_US
ethz.journal.abbreviated
Chem. commun.
ethz.pages.start
3895
en_US
ethz.pages.end
3898
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.grant
DNA Alkylation and Resistance in Antitumor Drug Toxicity
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Cambridge
en_US
ethz.publication.status
published
en_US
ethz.grant.agreementno
156280
ethz.grant.fundername
SNF
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.program
ethz.date.deposited
2019-04-19T01:41:17Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2019-04-23T14:53:58Z
ethz.rosetta.lastUpdated
2019-04-23T14:53:58Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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