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dc.contributor.author
Beil, Andreas
dc.contributor.author
Steudel, Friederike A.
dc.contributor.author
Bräuchle, Christoph
dc.contributor.author
Grützmacher, Hansjörg
dc.contributor.author
Möckl, Leonhard
dc.date.accessioned
2019-04-24T06:42:48Z
dc.date.available
2019-04-24T01:06:58Z
dc.date.available
2019-04-24T06:42:48Z
dc.date.issued
2019
dc.identifier.issn
2045-2322
dc.identifier.other
10.1038/s41598-019-42026-y
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/339164
dc.identifier.doi
10.3929/ethz-b-000339164
dc.description.abstract
Bisacylphosphane oxides (BAPOs) are established as photoinitiators for industrial applications. Light irradiation leads to their photolysis, producing radicals. Radical species induce oxidative stress in cells and may cause cell death. Hence, BAPOs may be suitable as photolatent cytotoxic agents, but such applications have not been investigated yet. Herein, we describe for the first time a potential use of BAPOs as drugs for photolatent therapy. We show that treatment of the breast cancer cell lines MCF-7 and MDA-MB-231 and of breast epithelial cells MCF-10A with BAPOs and UV irradiation induces apoptosis. Cells just subjected to BAPOs or UV irradiation alone are not affected. The induction of apoptosis depend on the BAPO and the irradiation dose. We proved that radicals are the active species since cells are rescued by an antioxidant. Finally, an optimized BAPO-derivative was designed which enters the cells more efficiently and thus leads to stronger effects at lower doses.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Nature
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
Bisacylphosphane oxides as photo-latent cytotoxic agents and potential photo-latent anticancer drugs
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2019-04-12
ethz.journal.title
Scientific Reports
ethz.journal.volume
9
en_US
ethz.journal.abbreviated
Sci Rep
ethz.pages.start
6003
en_US
ethz.size
11 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
London
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02513 - Laboratorium für Anorganische Chemie / Laboratory of Inorganic Chemistry::03447 - Grützmacher, Hansjörg / Grützmacher, Hansjörg
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02513 - Laboratorium für Anorganische Chemie / Laboratory of Inorganic Chemistry::03447 - Grützmacher, Hansjörg / Grützmacher, Hansjörg
ethz.date.deposited
2019-04-24T01:06:59Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2019-04-24T06:43:06Z
ethz.rosetta.lastUpdated
2024-02-02T07:42:11Z
ethz.rosetta.versionExported
true
ethz.COinS
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