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dc.contributor.author
Kulenkampff, Elisabeth
dc.contributor.author
Wolfrum, Christian
dc.date.accessioned
2019-05-28T10:03:07Z
dc.date.available
2019-05-16T17:32:08Z
dc.date.available
2019-05-28T10:03:07Z
dc.date.issued
2019
dc.identifier.other
10.1080/21623945.2018.1521229
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/342527
dc.identifier.doi
10.3929/ethz-b-000342527
dc.description.abstract
Adipose tissue is highly dynamic and increases its size dependent on the status of nutrition. Generally, an increase of adipose tissue mass is attributed to two mechanisms, namely hypertrophy (increase in adipocyte size) and hyperplasia (increase in adipocyte number). Here, we analyzed the proliferation capacity of a pool of nutrition sensing preadipocytes after short-term high fat diet (HFD) feeding. We show that this process is age independent and that adipocyte hyperplasia seems not to be dependent on adipocyte hypertrophy. Further, we could show that the subsequent development into adipocytes is influenced by the duration of HFD feeding after proliferation. Our data also demonstrate that the studied pool of preadipocytes seems to be finite and cannot be reactivated by multiple bouts of HFD feeding. In conclusion, our results indicate an important link between stem cells, nutrition status and homeostasis in the epididymal adipose tissue.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Taylor & Francis
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Epididymal adipose tissue
en_US
dc.subject
hyperplasia
en_US
dc.subject
hypertrophy
en_US
dc.subject
preadipocytes
en_US
dc.subject
nutrition sensing
en_US
dc.subject
proliferation and age
en_US
dc.subject
high fat diet (HFD)
en_US
dc.title
Proliferation of nutrition sensing preadipocytes upon short term HFD feeding
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2018-09-29
ethz.journal.title
Adipocyte
ethz.journal.volume
8
en_US
ethz.journal.issue
1
en_US
ethz.pages.start
16
en_US
ethz.pages.end
25
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.scopus
ethz.publication.place
Philadelphia, PA
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02701 - Inst.f. Lebensmittelwiss.,Ernährung,Ges. / Institute of Food, Nutrition, and Health::03819 - Wolfrum, Christian / Wolfrum, Christian
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02701 - Inst.f. Lebensmittelwiss.,Ernährung,Ges. / Institute of Food, Nutrition, and Health::03819 - Wolfrum, Christian / Wolfrum, Christian
ethz.date.deposited
2019-05-16T17:32:11Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2019-05-28T10:03:26Z
ethz.rosetta.lastUpdated
2020-02-15T19:21:24Z
ethz.rosetta.versionExported
true
ethz.COinS
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