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dc.contributor.author
Lenti, Elisa
dc.contributor.author
Bianchessi, Silvia
dc.contributor.author
Proulx, Steven T.
dc.contributor.author
Palano, Maria T.
dc.contributor.author
Genovese, Luca
dc.contributor.author
Raccosta, Laura
dc.contributor.author
Spinelli, Antonello
dc.contributor.author
Drago, Denise
dc.contributor.author
Andolfo, Annapaola
dc.contributor.author
Alfano, Massimo
dc.contributor.author
Petrova, Tatiana V.
dc.contributor.author
Mukenge, Sylvain
dc.contributor.author
Russo, Vincenzo
dc.contributor.author
Brendolan, Andrea
dc.date.accessioned
2019-06-13T08:26:27Z
dc.date.available
2019-06-13T02:15:47Z
dc.date.available
2019-06-13T08:26:27Z
dc.date.issued
2019-06-11
dc.identifier.other
10.1016/j.stemcr.2019.04.021
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/347172
dc.identifier.doi
10.3929/ethz-b-000347172
dc.description.abstract
Lymph nodes (LNs) are secondary lymphoid tissues that play a critical role in filtering the lymph and promoting adaptive immune responses. Surgical resection of LNs, radiation therapy, or infections may damage lymphatic vasculature and compromise immune functions. Here, we describe the generation of functional synthetic lympho-organoids (LOs) using LN stromal progenitors and decellularized extracellular matrix-based scaffolds, two basic constituents of secondary lymphoid tissues. We show that upon transplantation at the site of resected LNs, LOs become integrated into the endogenous lymphatic vasculature and efficiently restore lymphatic drainage and perfusion. Upon immunization, LOs support the activation of antigen-specific immune responses, thus acquiring properties of native lymphoid tissues. These findings provide a proof-of-concept strategy for the development of functional lympho-organoids suitable for restoring lymphatic and immune cell functions.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Elsevier
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.title
Therapeutic Regeneration of Lymphatic and Immune Cell Functions upon Lympho-organoid Transplantation
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
dc.date.published
2019-05-30
ethz.journal.title
Stem Cell Reports
ethz.journal.volume
12
en_US
ethz.journal.issue
6
en_US
ethz.pages.start
1260
en_US
ethz.pages.end
1268
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Amsterdam
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2019-06-13T02:15:49Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2019-06-13T08:26:38Z
ethz.rosetta.lastUpdated
2019-06-13T08:26:38Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.atitle=Therapeutic%20Regeneration%20of%20Lymphatic%20and%20Immune%20Cell%20Functions%20upon%20Lympho-organoid%20Transplantation&rft.jtitle=Stem%20Cell%20Reports&rft.date=2019-06-11&rft.volume=12&rft.issue=6&rft.spage=1260&rft.epage=1268&rft.au=Lenti,%20Elisa&Bianchessi,%20Silvia&Proulx,%20Steven%20T.&Palano,%20Maria%20T.&Genovese,%20Luca&rft.genre=article&
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