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dc.contributor.author
Baumann, Nicolas S.
dc.contributor.author
Welten, Suzanne P.M.
dc.contributor.author
Torti, Nicole
dc.contributor.author
Pallmer, Katharina
dc.contributor.author
Borsa, Mariana
dc.contributor.author
Barnstorf, Isabel
dc.contributor.author
Oduro, Jennifer D.
dc.contributor.author
Cicin-Sain, Luka
dc.contributor.author
Oxenius, Annette
dc.date.accessioned
2019-06-17T14:56:02Z
dc.date.available
2019-06-16T18:15:19Z
dc.date.available
2019-06-17T14:56:02Z
dc.date.issued
2019
dc.identifier.other
10.1371/journal.ppat.1007785
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/347645
dc.identifier.doi
10.3929/ethz-b-000347645
dc.description.abstract
Memory T cell inflation is a process in which a subset of cytomegalovirus (CMV) specific CD8 T cells continuously expands mainly during latent infection and establishes a large and stable population of effector memory cells in peripheral tissues. Here we set out to identify in vivo parameters that promote and limit CD8 T cell inflation in the context of MCMV infection. We found that the inflationary T cell pool comprised mainly high avidity CD8 T cells, outcompeting lower avidity CD8 T cells. Furthermore, the size of the inflationary T cell pool was not restricted by the availability of specific tissue niches, but it was directly related to the number of virus-specific CD8 T cells that were activated during priming. In particular, the amount of early-primed KLRG1- cells and the number of inflationary cells with a central memory phenotype were a critical determinant for the overall magnitude of the inflationary T cell pool. Inflationary memory CD8 T cells provided protection from a Vaccinia virus challenge and this protection directly correlated with the size of the inflationary memory T cell pool in peripheral tissues. These results highlight the remarkable protective potential of inflationary CD8 T cells that can be harnessed for CMV-based T cell vaccine approaches.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Public Library of Science
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
Early primed KLRG1- CMV-specific T cells determine the size of the inflationary T cell pool
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2019-03-13
ethz.journal.title
PLoS pathogens
ethz.journal.volume
15
en_US
ethz.journal.issue
5
en_US
ethz.pages.start
e1007785
en_US
ethz.size
23 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.grant
Regulation of adaptive immunity during acute and persistent viral infections
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
San Francisco, CA
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02520 - Institut für Mikrobiologie / Institute of Microbiology::03625 - Oxenius, Annette / Oxenius, Annette
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02520 - Institut für Mikrobiologie / Institute of Microbiology::03625 - Oxenius, Annette / Oxenius, Annette
ethz.grant.agreementno
146140
ethz.grant.fundername
SNF
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.program
Projektförderung in Biologie und Medizin (Abteilung III)
ethz.date.deposited
2019-06-16T18:15:22Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2019-06-17T14:56:16Z
ethz.rosetta.lastUpdated
2020-02-15T19:43:02Z
ethz.rosetta.versionExported
true
ethz.COinS
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