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dc.contributor.author
Kosse, Christin
dc.contributor.author
Burdakov, Denis
dc.date.accessioned
2019-06-20T07:35:13Z
dc.date.available
2019-06-20T02:27:41Z
dc.date.available
2019-06-20T07:35:13Z
dc.date.issued
2019
dc.identifier.issn
2041-1723
dc.identifier.other
10.1038/s41467-019-10484-7
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/348586
dc.identifier.doi
10.3929/ethz-b-000348586
dc.description.abstract
Brain signals that govern memory formation remain incompletely identified. The hypothalamus is implicated in memory disorders, but how its rapidly changing activity shapes memorization is unknown. During encounters with objects, hypothalamic melanin-concentrating hormone (MCH) neurons emit brief signals that reflect object novelty. Here we show that targeted optogenetic silencing of these signals, performed selectively during the initial object encounters (i.e. memory acquisition), prevents future recognition of the objects. We identify an upstream inhibitory microcircuit from hypothalamic GAD65 neurons to MCH neurons, which constrains the memory-promoting MCH cell bursts. Finally, we demonstrate that silencing the GAD65 cells during object memory acquisition improves future object recognition through MCH-receptor-dependent pathways. These results provide causal evidence that object-associated signals in genetically distinct but interconnected hypothalamic neurons differentially control whether the brain forms object memories. This gating of memory formation by hypothalamic activity establishes appropriate behavioral responses to novel and familiar objects.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Nature Publishing Group
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
Natural hypothalamic circuit dynamics underlying object memorization
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2019-06-07
ethz.journal.title
Nature Communications
ethz.journal.volume
10
en_US
ethz.journal.abbreviated
Nat Commun
ethz.pages.start
2505
en_US
ethz.size
8 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
London
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02542 - Institut für Neurowissenschaften / Institute for Neuroscience::09589 - Burdakov, Denis / Burdakov, Denis
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02542 - Institut für Neurowissenschaften / Institute for Neuroscience::09589 - Burdakov, Denis / Burdakov, Denis
ethz.date.deposited
2019-06-20T02:27:44Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2019-06-20T07:35:26Z
ethz.rosetta.lastUpdated
2020-02-15T19:44:59Z
ethz.rosetta.versionExported
true
ethz.COinS
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