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dc.contributor.author
Lanzoni, Anna
dc.contributor.author
Castoldi, Anna F.
dc.contributor.author
Kass, George E.N.
dc.contributor.author
Terron, Andrea
dc.contributor.author
De Seze, Guilhem
dc.contributor.author
Bal‐Price, Anna
dc.contributor.author
Bois, Frédéric Y.
dc.contributor.author
Delclos, K. Barry
dc.contributor.author
Doerge, Daniel R.
dc.contributor.author
Fritsche, Ellen
dc.contributor.author
Halldorsson, Thorhallur
dc.contributor.author
Kolossa-Gehring, Marike
dc.contributor.author
Hougaard Bennekou, Susanne
dc.contributor.author
Koning, Frits
dc.contributor.author
Lampen, Alfonso
dc.contributor.author
Leist, Marcel
dc.contributor.author
Mantus, Ellen
dc.contributor.author
Rousselle, Christophe
dc.contributor.author
Siegrist, Michael
dc.contributor.author
Steinberg, Pablo
dc.contributor.author
Tritscher, Angelika
dc.contributor.author
Van de Water, Bob
dc.contributor.author
Vineis, Paolo
dc.contributor.author
Walker, Nigel
dc.contributor.author
Wallace, Heather
dc.contributor.author
Whelan, Maurice
dc.contributor.author
Younes, Maged
dc.contributor.editor
Devos, Yann
dc.contributor.editor
Elliott, Kevin
dc.contributor.editor
Hardy, Anthony
dc.date.accessioned
2019-07-23T12:48:43Z
dc.date.available
2019-07-20T02:53:53Z
dc.date.available
2019-07-23T12:37:46Z
dc.date.available
2019-07-23T12:48:43Z
dc.date.issued
2019-07
dc.identifier.issn
1831-4732
dc.identifier.other
10.2903/j.efsa.2019.e170712
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/354209
dc.identifier.doi
10.3929/ethz-b-000354209
dc.description.abstract
The current/traditional human health risk assessment paradigm is challenged by recent scientific and technical advances, and ethical demands. The current approach is considered too resource intensive, is not always reliable, can raise issues of reproducibility, is mostly animal based and does not necessarily provide an understanding of the underlying mechanisms of toxicity. From an ethical and scientific viewpoint, a paradigm shift is required to deliver testing strategies that enable reliable, animal‐free hazard and risk assessments, which are based on a mechanistic understanding of chemical toxicity and make use of exposure science and epidemiological data. This shift will require a new philosophy, new data, multidisciplinary expertise and more flexible regulations. Re‐engineering of available data is also deemed necessary as data should be accessible, readable, interpretable and usable. Dedicated training to build the capacity in terms of expertise is necessary, together with practical resources allocated to education. The dialogue between risk assessors, risk managers, academia and stakeholders should be promoted further to understand scientific and societal needs. Genuine interest in taking risk assessment forward should drive the change and should be supported by flexible funding. This publication builds upon presentations made and discussions held during the break‐out session ‘Advancing risk assessment science – Human health’ at EFSA's third Scientific Conference ‘Science, Food and Society’ (Parma, Italy, 18–21 September 2018).
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Wiley
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nd/4.0/
dc.subject
Alternative methods
en_US
dc.subject
Exposure
en_US
dc.subject
Epidemiology
en_US
dc.subject
Food safety
en_US
dc.subject
Mechanistic studies
en_US
dc.subject
Risk assessment
en_US
dc.title
Advancing human health risk assessment
en_US
dc.type
Conference Paper
dc.rights.license
Creative Commons Attribution-NoDerivatives 4.0 International
dc.date.published
2019-07-08
ethz.book.title
Proceedings of the Third EFSA Scientific Conference: Science, Food and Society
en_US
ethz.journal.title
EFSA Journal
ethz.journal.volume
17
en_US
ethz.journal.issue
S1
en_US
ethz.pages.start
e170712
en_US
ethz.size
21 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.event
The Third EFSA Scientific Conference: Science, Food and Society (EFSA 2018)
en_US
ethz.event.location
Parma, Italy
en_US
ethz.event.date
September 18-21, 2018
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Oxford
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2019-07-20T02:53:56Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2019-07-23T12:37:54Z
ethz.rosetta.lastUpdated
2020-02-15T20:25:14Z
ethz.rosetta.versionExported
true
ethz.COinS
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