Show simple item record

dc.contributor.author
Giannini, Cinzia
dc.contributor.author
Terzi, Alberta
dc.contributor.author
Fusaro, Luca
dc.contributor.author
Sibillano, Teresa
dc.contributor.author
Diaz, Ana
dc.contributor.author
Ramella, Martina
dc.contributor.author
Lutz-Bueno, Viviane
dc.contributor.author
Boccafoschi, Francesca
dc.contributor.author
Bunk, Oliver
dc.date.accessioned
2019-10-07T12:51:37Z
dc.date.available
2019-08-08T02:06:49Z
dc.date.available
2019-08-08T11:22:00Z
dc.date.available
2019-10-07T12:51:37Z
dc.date.issued
2019-10
dc.identifier.other
10.1002/jbio.201900106
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/357238
dc.identifier.doi
10.3929/ethz-b-000357238
dc.description.abstract
Blood glucose supplies energy to cells and is critical for the human brain. Glycation of collagen, the nonenzymatic formation of glucose‐bridges, relates to diseases of aging populations and diabetics. This chemical reaction, together with its biomechanical effects, has been well studied employing animal models. However, the direct impact of glycation on collagen nano‐structure is largely overlooked, and there is a lack of ex vivo model systems. Here, we present the impact of glucose on collagen nanostructure in a model system based on abundantly available connective tissue of farm animals. By combining ex vivo small and wide‐angle X‐ray scattering (SAXS/WAXS) imaging, we characterize intra‐ and inter‐molecular parameters of collagen in decellularized bovine pericardium with picometer precision. We observe three distinct regimes according to glucose concentration. Such a study opens new avenues for inspecting the effects of diabetes mellitus on connective tissues and the influence of therapies on the resulting secondary disorders.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Wiley
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject
Collagen
en_US
dc.subject
Diabetes
en_US
dc.subject
Pericardium
en_US
dc.subject
SAXS
en_US
dc.subject
Scanning microscopy
en_US
dc.subject
WAXS
en_US
dc.title
Scanning X‐ray microdiffraction of decellularized pericardium tissue at increasing glucose concentration
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
dc.date.published
2018-06-18
ethz.journal.title
Journal of Biophotonics
ethz.journal.volume
12
en_US
ethz.journal.issue
10
en_US
ethz.pages.start
e201900106
en_US
ethz.size
12 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.publication.place
Weinheim
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2019-08-08T02:06:53Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2019-10-07T12:52:09Z
ethz.rosetta.lastUpdated
2019-10-07T12:52:09Z
ethz.rosetta.versionExported
true
ethz.COinS
ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.atitle=Scanning%20X%E2%80%90ray%20microdiffraction%20of%20decellularized%20pericardium%20tissue%20at%20increasing%20glucose%20concentration&rft.jtitle=Journal%20of%20Biophotonics&rft.date=2019-10&rft.volume=12&rft.issue=10&rft.spage=e201900106&rft.au=Giannini,%20Cinzia&Terzi,%20Alberta&Fusaro,%20Luca&Sibillano,%20Teresa&Diaz,%20Ana&rft.genre=article&
 Search via SFX

Files in this item

Thumbnail

Publication type

Show simple item record