Preclinical Evaluation of Benzazepine-Based PET Radioligands (R)- and (S)-11C-Me-NB1 Reveals Distinct Enantiomeric Binding Patterns and a Tightrope Walk Between GluN2B- and σ1-Receptor–Targeted PET Imaging

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Author
Haider, Ahmed
Müller Herde, Adrienne
Krämer, Stefanie D.
Varisco, Jasmine
Keller, Claudia
Frauenknecht, Katrin
Auberson, Yves P.
Temme, Louisa
Robaa, Dina
Sippl, Wolfgang
Schibli, Roger
Wünsch, Bernhard
Mu, Linjingcc
Ametamey, Simon M.
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Date
2019-08-01
Type
    Journal Article
Publication status
published
External links
Journal / series
The Journal of Nuclear Medicine
Volume
60(8)
Pages / Article No.
1167 - 1173
Publisher
Society of Nuclear Medicine
Subject
PET imaging; GluN2B; σ1-receptor; Receptor occupancy; Neurodegeneration
Organisational unit
03688 - Schibli, Roger / Schibli, Roger  
Funding
160403 - Development of fluorinated GluN2B receptorantagonists for positron emission tomography (SNF)
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Citations
Cited 27 times in Scopus
ETH Bibliography
yes
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