Carbon-nanotube-based monolithic CMOS platform for electrochemical detection of neurotransmitter glutamate
- Journal Article
Rights / licenseCreative Commons Attribution 4.0 International
We present a monolithic biosensor platform, based on carbon-nanotube field-effect transistors (CNTFETs), for the detection of the neurotransmitter glutamate. We used an array of 9′216 CNTFET devices with 96 integrated readout and amplification channels that was realized in complementary metal-oxide semiconductor technology (CMOS). The detection principle is based on amperometry, where electrochemically active hydrogen peroxide, a product of the enzymatic reaction of the target analyte and an enzyme that was covalently bonded to the CNTFET, modulated the conductance of the CNTFET-based sensors. We assessed the performance of the CNTs as enzymatic sensors by evaluating the minimal resolvable concentration change of glutamate in aqueous solutions. The minimal resolvable concentration change amounted to 10 µM of glutamate, which was one of the best values reported for CMOS-based systems so far. Show more
Journal / seriesSensors
Pages / Article No.
SubjectCarbon nanotube field-effect transistor; CMOS; Ion-sensitive field-effect transistors; ChemFET
Organisational unit02060 - Dep. Biosysteme / Dep. of Biosystems Science and Eng.
694829 - Microtechnology and integrated microsystems to investigate neuronal networks across scales (EC)
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