Show simple item record

dc.contributor.author
Dudina, Alexandra
dc.contributor.author
Frey, Urs
dc.contributor.author
Hierlemann, Andreas
dc.date.accessioned
2019-08-13T08:42:52Z
dc.date.available
2019-08-13T08:39:37Z
dc.date.available
2019-08-13T08:42:52Z
dc.date.issued
2019-07
dc.identifier.issn
1424-8220
dc.identifier.other
10.3390/s19143080
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/358118
dc.identifier.doi
10.3929/ethz-b-000358118
dc.description.abstract
We present a monolithic biosensor platform, based on carbon-nanotube field-effect transistors (CNTFETs), for the detection of the neurotransmitter glutamate. We used an array of 9′216 CNTFET devices with 96 integrated readout and amplification channels that was realized in complementary metal-oxide semiconductor technology (CMOS). The detection principle is based on amperometry, where electrochemically active hydrogen peroxide, a product of the enzymatic reaction of the target analyte and an enzyme that was covalently bonded to the CNTFET, modulated the conductance of the CNTFET-based sensors. We assessed the performance of the CNTs as enzymatic sensors by evaluating the minimal resolvable concentration change of glutamate in aqueous solutions. The minimal resolvable concentration change amounted to 10 µM of glutamate, which was one of the best values reported for CMOS-based systems so far.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
MDPI
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Carbon nanotube field-effect transistor
en_US
dc.subject
CMOS
en_US
dc.subject
Ion-sensitive field-effect transistors
en_US
dc.subject
ChemFET
en_US
dc.title
Carbon-nanotube-based monolithic CMOS platform for electrochemical detection of neurotransmitter glutamate
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2019-07-12
ethz.journal.title
Sensors
ethz.journal.volume
19
en_US
ethz.journal.issue
14
en_US
ethz.pages.start
3080
en_US
ethz.size
13 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.grant
Microtechnology and integrated microsystems to investigate neuronal networks across scales
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Basel
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02060 - Dep. Biosysteme / Dep. of Biosystems Science and Eng.
en_US
ethz.grant.agreementno
694829
ethz.grant.fundername
EC
ethz.grant.funderDoi
10.13039/501100000780
ethz.grant.program
H2020
ethz.date.deposited
2019-08-13T08:39:44Z
ethz.source
FORM
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2019-08-13T08:43:08Z
ethz.rosetta.lastUpdated
2019-08-13T08:43:08Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.atitle=Carbon-nanotube-based%20monolithic%20CMOS%20platform%20for%20electrochemical%20detection%20of%20neurotransmitter%20glutamate&rft.jtitle=Sensors&rft.date=2019-07&rft.volume=19&rft.issue=14&rft.spage=3080&rft.issn=1424-8220&rft.au=Dudina,%20Alexandra&Frey,%20Urs&Hierlemann,%20Andreas&rft.genre=article&
 Search via SFX

Files in this item

Thumbnail

Publication type

Show simple item record