Thoma, Claudio R.
- Review Article
Aneuploidy, as a result of numerical changes in chromosome number, was observed in tumours almost a century ago. The molecular mechanisms underlying this phenomenon and their impact on tumour development are still poorly understood. A series of recent observations provide direct linkages between the normal function of tumour suppressor proteins and the suppression of aneuploidy. The prospects that these findings offer for understanding the role of aneuploidy in cancer are discussed in this review Show more
Journal / seriesSwiss Medical Weekly
Pages / Article No.
PublisherEMH, Schweizerischer Ärzte-Verlag AG
SubjectAneuploidy; Whole chromosomal instability; Tumour suppressor proteins
Organisational unit03745 - Meraldi, Patrick (SNF-Professur)
03630 - Krek, Wilhelm
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