Mechanisms of aneuploidy and its suppression by tumour suppressor proteins
dc.contributor.author
Thoma, Claudio R.
dc.contributor.author
Toso, Alberto
dc.contributor.author
Meraldi, Patrick
dc.contributor.author
Krek, Wilhelm
dc.date.accessioned
2018-03-23T09:47:24Z
dc.date.available
2017-06-09T11:23:51Z
dc.date.available
2018-03-23T09:47:24Z
dc.date.issued
2011-03-08
dc.identifier.issn
1424-7860
dc.identifier.issn
1424-3997
dc.identifier.other
10.4414/smw.2011.13170
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/35814
dc.identifier.doi
10.3929/ethz-b-000035814
dc.description.abstract
Aneuploidy, as a result of numerical changes in chromosome number, was observed in tumours almost a century ago. The molecular mechanisms underlying this phenomenon and their impact on tumour development are still poorly understood. A series of recent observations provide direct linkages between the normal function of tumour suppressor proteins and the suppression of aneuploidy. The prospects that these findings offer for understanding the role of aneuploidy in cancer are discussed in this review.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
EMH Schweizerischer Ärzteverlag
dc.rights.uri
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject
Aneuploidy
en_US
dc.subject
Whole chromosomal instability
en_US
dc.subject
Tumour suppressor proteins
en_US
dc.title
Mechanisms of aneuploidy and its suppression by tumour suppressor proteins
en_US
dc.type
Review Article
dc.rights.license
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
ethz.journal.title
Swiss Medical Weekly
ethz.journal.volume
141
en_US
ethz.journal.abbreviated
Swiss Med Wkly
ethz.pages.start
w13170
en_US
ethz.size
8 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.nebis
004068353
ethz.publication.place
Basel
ethz.publication.status
published
en_US
ethz.leitzahl
03745 - Meraldi, Patrick (SNF-Professur)
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02539 - Institut für Molecular Health Sciences / Institute of Molecular Health Sciences::03630 - Krek, Wilhelm (ehemalig) / Krek, Wilhelm (former)
en_US
ethz.leitzahl.certified
03745 - Meraldi, Patrick (SNF-Professur)
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02539 - Institut für Molecular Health Sciences / Institute of Molecular Health Sciences::03630 - Krek, Wilhelm (ehemalig) / Krek, Wilhelm (former)
ethz.date.deposited
2017-06-09T11:24:15Z
ethz.source
ECIT
ethz.identifier.importid
imp59364e197b23b22363
ethz.ecitpid
pub:57354
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-15T01:55:24Z
ethz.rosetta.lastUpdated
2019-02-02T16:21:27Z
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true
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