Regulation of wound healing by the NRF2 transcription factor - more than cytoprotection

Open access
Date
2019-08Type
- Journal Article
Citations
Cited 28 times in
Web of Science
Cited 26 times in
Scopus
ETH Bibliography
yes
Altmetrics
Abstract
The nuclear factor-erythroid 2-related factor 2 (NRF2) transcription factor plays a central role in mediating the cellular stress response. Due to their antioxidant properties, compounds activating NRF2 have received much attention as potential medications for disease prevention, or even for therapy. Accumulating evidence suggests that activation of the NRF2 pathway also has a major impact on wound healing and may be beneficial in the treatment of chronic wounds, which remain a considerable health and economic burden. While NRF2 activation indeed shows promise, important considerations need to be made in light of corresponding evidence that also points towards pro-tumorigenic effects of NRF2. In this review, we discuss the evidence to date, highlighting recent advances using gain- and loss-of-function animal models and how these data fit with observations in humans. Show more
Permanent link
https://doi.org/10.3929/ethz-b-000358163Publication status
publishedExternal links
Journal / series
International Journal of Molecular SciencesVolume
Pages / Article No.
Publisher
MDPISubject
NRF2; Wound healing; Keratinocyte; Fibroblast; InflammationOrganisational unit
02030 - Dep. Biologie / Dep. of Biology03520 - Werner, Sabine / Werner, Sabine
Funding
169204 - Role of cytokines and environmental cues in wound repair and inflammatory skin disease (SNF)
More
Show all metadata
Citations
Cited 28 times in
Web of Science
Cited 26 times in
Scopus
ETH Bibliography
yes
Altmetrics