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dc.contributor.author
Hiebert, Paul
dc.contributor.author
Werner, Sabine
dc.date.accessioned
2019-08-13T09:55:33Z
dc.date.available
2019-08-13T09:52:44Z
dc.date.available
2019-08-13T09:55:33Z
dc.date.issued
2019-08
dc.identifier.issn
1422-0067
dc.identifier.other
10.3390/ijms20163856
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/358163
dc.identifier.doi
10.3929/ethz-b-000358163
dc.description.abstract
The nuclear factor-erythroid 2-related factor 2 (NRF2) transcription factor plays a central role in mediating the cellular stress response. Due to their antioxidant properties, compounds activating NRF2 have received much attention as potential medications for disease prevention, or even for therapy. Accumulating evidence suggests that activation of the NRF2 pathway also has a major impact on wound healing and may be beneficial in the treatment of chronic wounds, which remain a considerable health and economic burden. While NRF2 activation indeed shows promise, important considerations need to be made in light of corresponding evidence that also points towards pro-tumorigenic effects of NRF2. In this review, we discuss the evidence to date, highlighting recent advances using gain- and loss-of-function animal models and how these data fit with observations in humans.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
MDPI
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
NRF2
en_US
dc.subject
Wound healing
en_US
dc.subject
Keratinocyte
en_US
dc.subject
Fibroblast
en_US
dc.subject
Inflammation
en_US
dc.title
Regulation of wound healing by the NRF2 transcription factor - more than cytoprotection
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2019-08-08
ethz.journal.title
International Journal of Molecular Sciences
ethz.journal.volume
20
en_US
ethz.journal.issue
16
en_US
ethz.journal.abbreviated
Int. j. mol. sci.
ethz.pages.start
3856
en_US
ethz.size
13 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.grant
Role of cytokines and environmental cues in wound repair and inflammatory skin disease
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Basel
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02539 - Institut für Molecular Health Sciences / Institute of Molecular Health Sciences::03520 - Werner, Sabine / Werner, Sabine
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02539 - Institut für Molecular Health Sciences / Institute of Molecular Health Sciences::03520 - Werner, Sabine / Werner, Sabine
ethz.grant.agreementno
169204
ethz.grant.fundername
SNF
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.program
Projekte Lebenswissenschaften
ethz.date.deposited
2019-08-13T09:52:50Z
ethz.source
FORM
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2019-08-13T09:55:41Z
ethz.rosetta.lastUpdated
2022-03-28T23:27:48Z
ethz.rosetta.versionExported
true
ethz.COinS
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