Show simple item record

dc.contributor.author
Grozdanić, Marija
dc.contributor.author
Vidmar, Robert
dc.contributor.author
Vizovišek, Matej
dc.contributor.author
Fonović, Marko
dc.date.accessioned
2021-03-12T09:44:42Z
dc.date.available
2019-08-25T02:14:51Z
dc.date.available
2019-08-26T13:37:16Z
dc.date.available
2019-11-25T16:47:54Z
dc.date.available
2021-03-12T09:44:42Z
dc.date.issued
2019-11
dc.identifier.issn
1862-8346
dc.identifier.issn
1862-8354
dc.identifier.other
10.1002/prca.201800138
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/360366
dc.description.abstract
The upregulation of protease expression and proteolytic activity is implicated in numerous pathological conditions such as neurodegeneration, cancer, cardiovascular and autoimmune diseases, and bone degeneration. During disease progression, various proteases form characteristic patterns of cleaved proteins and peptides, which can affect disease severity and course of progression. It has been shown that qualitative and quantitative monitoring of cleaved protease substrates can provide relevant prognostic, diagnostic, and therapeutic information. As proteolytic fragments and peptides generated in the affected tissue are commonly translocated to blood, urine, and other proximal fluids, their possible application as biomarkers is the subject of ongoing research. The field of degradomics has been established to enable the global identification of proteolytic events on the organism level, utilizing proteomic approaches and sample preparation techniques that facilitate the detection of proteolytic processing of protease substrates in complex biological samples. In this review, some of the latest developments in degradomic methodologies used for the identification and validation of biologically relevant proteolytic events and their application in the search for clinically relevant biomarker candidates are presented. The current state of degradomics in clinics is discussed and the future perspectives of the field are outlined.
en_US
dc.language.iso
en
en_US
dc.publisher
Wiley
en_US
dc.subject
biomarker
en_US
dc.subject
degradomics
en_US
dc.subject
protease
en_US
dc.subject
proteomics
en_US
dc.subject
substrate
en_US
dc.title
Degradomics in Biomarker Discovery
en_US
dc.type
Review Article
dc.date.published
2019-07-10
ethz.journal.title
Proteomics. Clinical Applications
ethz.journal.volume
13
en_US
ethz.journal.issue
6
en_US
ethz.journal.abbreviated
Prot. Clin. Appl.
ethz.pages.start
1800138
en_US
ethz.size
11 p.
en_US
ethz.identifier.wos
ethz.publication.place
Weinheim
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2019-08-25T02:14:55Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.installDate
2019-11-25T16:48:05Z
ethz.rosetta.lastUpdated
2022-03-29T05:44:41Z
ethz.rosetta.versionExported
true
ethz.COinS
ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.atitle=Degradomics%20in%20Biomarker%20Discovery&rft.jtitle=Proteomics.%20Clinical%20Applications&rft.date=2019-11&rft.volume=13&rft.issue=6&rft.spage=1800138&rft.issn=1862-8346&1862-8354&rft.au=Grozdani%C4%87,%20Marija&Vidmar,%20Robert&Vizovi%C5%A1ek,%20Matej&Fonovi%C4%87,%20Marko&rft.genre=article&rft_id=info:doi/10.1002/prca.201800138&
 Search print copy at ETH Library

Files in this item

FilesSizeFormatOpen in viewer

There are no files associated with this item.

Publication type

Show simple item record