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dc.contributor.author
Helleboid, Pierre-Yves
dc.contributor.author
Heusel, Moritz
dc.contributor.author
Duc, Julien
dc.contributor.author
Piot, Cecile
dc.contributor.author
Thorball, Christian W.
dc.contributor.author
Coluccio, Andrea
dc.contributor.author
Pontis, Julien
dc.contributor.author
Turelli, Priscilla
dc.contributor.author
Aebersold, Ruedi
dc.contributor.author
Trono, Didier
dc.date.accessioned
2019-09-20T14:40:51Z
dc.date.available
2019-08-27T08:19:55Z
dc.date.available
2019-08-27T09:10:14Z
dc.date.available
2019-09-20T14:40:51Z
dc.date.issued
2019-09-16
dc.identifier.issn
0261-4189
dc.identifier.issn
1460-2075
dc.identifier.other
10.15252/embj.2018101220
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/360670
dc.identifier.doi
10.3929/ethz-b-000360670
dc.description.abstract
Krüppel‐associated box (KRAB)‐containing zinc finger proteins (KZFPs) are encoded in the hundreds by the genomes of higher vertebrates, and many act with the heterochromatin‐inducing KAP1 as repressors of transposable elements (TEs) during early embryogenesis. Yet, their widespread expression in adult tissues and enrichment at other genetic loci indicate additional roles. Here, we characterized the protein interactome of 101 of the ~350 human KZFPs. Consistent with their targeting of TEs, most KZFPs conserved up to placental mammals essentially recruit KAP1 and associated effectors. In contrast, a subset of more ancient KZFPs rather interacts with factors related to functions such as genome architecture or RNA processing. Nevertheless, KZFPs from coelacanth, our most distant KZFP‐encoding relative, bind the cognate KAP1. These results support a hypothetical model whereby KZFPs first emerged as TE‐controlling repressors, were continuously renewed by turnover of their hosts’ TE loads, and occasionally produced derivatives that escaped this evolutionary flushing by development and exaptation of novel functions.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Wiley
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Coelacanth
en_US
dc.subject
Evolution
en_US
dc.subject
KAP1
en_US
dc.subject
KRAB zinc finger proteins
en_US
dc.subject
Mass spectrometry
en_US
dc.title
The interactome of KRAB zinc finger proteins reveals the evolutionary history of their functional diversification
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2019-08-12
ethz.journal.title
The EMBO Journal
ethz.journal.volume
38
en_US
ethz.journal.issue
18
en_US
ethz.journal.abbreviated
EMBO J
ethz.pages.start
e101220
en_US
ethz.size
16 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.grant
Proteomics 4D: The proteome in context
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Chichester
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02538 - Institut für Molekulare Systembiologie / Institute for Molecular Systems Biology::03663 - Aebersold, Rudolf (emeritus) / Aebersold, Rudolf (emeritus)
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02538 - Institut für Molekulare Systembiologie / Institute for Molecular Systems Biology::03663 - Aebersold, Rudolf (emeritus) / Aebersold, Rudolf (emeritus)
ethz.grant.agreementno
670821
ethz.grant.fundername
EC
ethz.grant.funderDoi
10.13039/501100000780
ethz.grant.program
H2020
ethz.date.deposited
2019-08-27T08:19:59Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2019-09-20T14:41:20Z
ethz.rosetta.lastUpdated
2022-03-28T23:40:42Z
ethz.rosetta.versionExported
true
ethz.COinS
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