Leukemia On Chip - Electrical Impedance Spectroscopy As An Online Readout To Investigate Drug-Cancer Interaction
- Conference Paper
Based on recent advances in the field of microphysiological systems, we established a Leukemia-on-chip concept to mimic blood cancer in vitro by continuously circulating leukemia cells in a microfluidic system. This platform is complemented by an integrated electrical-impedance-spectroscopy (EIS) unit that enables to monitor the flowing cancer cells in real-time. The electric parameters, such as membrane conductivity and dielectric properties, alter upon the death of leukemia cells. Thus, drug-cancer interactions can be studied online and label-free by means of EIS. In this study, we present proof-of-concept experimental results that show the potential of EIS for real-time drug efficacy research. © 2019 IEEE. Show more
Book titleProceedings of the 20th International Conference on Solid-State Sensors, Actuators and Microsystems & Eurosensors XXXIII (TRANSDUCERS & EUROSENSORS XXXIII)
Pages / Article No.
SubjectElectrical impedance spectroscopy; leukemia; drug screening; microphysiological systems; drug efficacy
Organisational unit03684 - Hierlemann, Andreas / Hierlemann, Andreas
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