Show simple item record

dc.contributor.author
Yoon, Sun-Young
dc.contributor.author
Dieterich, Lothar C.
dc.contributor.author
Tacconi, Carlotta
dc.contributor.author
Sesartic, Marko
dc.contributor.author
He, Yuliang
dc.contributor.author
Brunner, Lorenz
dc.contributor.author
Kwon, Ohsang
dc.contributor.author
Detmar, Michael
dc.date.accessioned
2019-09-30T08:27:41Z
dc.date.available
2019-09-28T08:12:24Z
dc.date.available
2019-09-30T08:27:41Z
dc.date.issued
2019
dc.identifier.issn
1932-6203
dc.identifier.other
10.1371/journal.pone.0219938
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/367060
dc.identifier.doi
10.3929/ethz-b-000367060
dc.description.abstract
Podoplanin (PDPN) is a glycoprotein that is expressed by various cell types, including keratinocytes, fibroblasts, and lymphatic endothelial cells. We found that PDPN is expressed in the hair follicle (HF) keratinocyte region and HF stem cell area during the late anagen phase but not during the telogen phase in mice. Importantly, keratinocyte-specific PDPN deletion in mice (K5-Cre;PDPNflox/flox) promoted anagen HF growth after depilation-induced HF regeneration as compared to control mice. RNA sequencing, followed by gene ontology analysis, showed down-regulation of focal adhesion and extracellular matrix interaction pathways in HF stem cells isolated from K5-Cre;PDPNflox/flox mice as compared to control mice. Furthermore, HF keratinocytes isolated from K5-Cre;PDPNflox/flox mice exhibited a decreased ability to interact with collagen type I in cell adhesion assays. Taken together, these results show that PDPN deletion promotes HF cycling, possibly via reduced focal adhesion and concomitantly enhanced migration of HF stem cells towards the bulb region. They also indicate potential new therapeutic strategies for the treatment of conditions associated with hair loss.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Public Library of Science
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
An important role of podoplanin in hair follicle growth
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2019-07-23
ethz.journal.title
PLoS ONE
ethz.journal.volume
14
en_US
ethz.journal.issue
7
en_US
ethz.journal.abbreviated
PLoS ONE
ethz.pages.start
e0219938
en_US
ethz.size
12 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.grant
Molecular mechanisms of angiogenesis and lymphangiogenesis in inflammation and cancer progression
en_US
ethz.identifier.wos
ethz.publication.place
San Francisco, CA
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02534 - Institut für Pharmazeutische Wiss. / Institute of Pharmaceutical Sciences::03683 - Detmar, Michael / Detmar, Michael
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02534 - Institut für Pharmazeutische Wiss. / Institute of Pharmaceutical Sciences::03683 - Detmar, Michael / Detmar, Michael
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02534 - Institut für Pharmazeutische Wiss. / Institute of Pharmaceutical Sciences::03683 - Detmar, Michael / Detmar, Michael
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02534 - Institut für Pharmazeutische Wiss. / Institute of Pharmaceutical Sciences::03683 - Detmar, Michael / Detmar, Michael
ethz.grant.agreementno
130627
ethz.grant.fundername
SNF
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.program
Projektförderung in Biologie und Medizin (Abteilung III)
ethz.date.deposited
2019-09-28T08:12:34Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2019-09-30T08:28:03Z
ethz.rosetta.lastUpdated
2020-02-15T21:49:23Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.atitle=An%20important%20role%20of%20podoplanin%20in%20hair%20follicle%20growth&rft.jtitle=PLoS%20ONE&rft.date=2019&rft.volume=14&rft.issue=7&rft.spage=e0219938&rft.issn=1932-6203&rft.au=Yoon,%20Sun-Young&Dieterich,%20Lothar%20C.&Tacconi,%20Carlotta&Sesartic,%20Marko&He,%20Yuliang&rft.genre=article&
 Search via swisscovery

Files in this item

Thumbnail

Publication type

Show simple item record