A hybrid sub-lineage of Listeria monocytogenes comprising hypervirulent isolates
dc.contributor.author
Yin, Yuelan
dc.contributor.author
Yao, Hao
dc.contributor.author
Doijad, Swapnil
dc.contributor.author
Kong, Suwei
dc.contributor.author
Shen, Yang
dc.contributor.author
Cai, Xuexue
dc.contributor.author
Tan, Weijun
dc.contributor.author
Wang, Yuting
dc.contributor.author
Feng, Youwei
dc.contributor.author
Ling, Zhiting
dc.contributor.author
Wang, Guoliang
dc.contributor.author
Hu, Yachen
dc.contributor.author
Lian, Kai
dc.contributor.author
Sun, Xinyu
dc.contributor.author
Liu, Yuliang
dc.contributor.author
Wang, Chuanbin
dc.contributor.author
Jiao, Kuhua
dc.contributor.author
Liu, Guoping
dc.contributor.author
Song, Ruilong
dc.contributor.author
Chen, Xiang
dc.contributor.author
Pan, Zhiming
dc.contributor.author
Loessner, Martin J.
dc.contributor.author
Chakraborty, Trinad
dc.contributor.author
Jiao, Xin’an
dc.date.accessioned
2019-10-08T07:37:02Z
dc.date.available
2019-10-08T02:41:30Z
dc.date.available
2019-10-08T07:37:02Z
dc.date.issued
2019-09-30
dc.identifier.issn
2041-1723
dc.identifier.other
10.1038/s41467-019-12072-1
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/368939
dc.identifier.doi
10.3929/ethz-b-000368939
dc.description.abstract
The foodborne pathogen Listeria monocytogenes (Lm) is a highly heterogeneous species and currently comprises of 4 evolutionarily distinct lineages. Here, we characterize isolates from severe ovine listeriosis outbreaks that represent a hybrid sub-lineage of the major lineage II (HSL-II) and serotype 4h. HSL-II isolates are highly virulent and exhibit higher organ colonization capacities than well-characterized hypervirulent strains of Lm in an orogastric mouse infection model. The isolates harbour both the Lm Pathogenicity Island (LIPI)-1 and a truncated LIPI-2 locus, encoding sphingomyelinase (SmcL), a virulence factor required for invasion and bacterial translocation from the gut, and other non-contiguous chromosomal segments from another pathogenic species, L. ivanovii. HSL-II isolates exhibit a unique wall teichoic acid (WTA) structure essential for resistance to antimicrobial peptides, bacterial invasion and virulence. The discovery of isolates harbouring pan-species virulence genes of the genus Listeria warrants global efforts to identify further hypervirulent lineages of Lm.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Nature
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
A hybrid sub-lineage of Listeria monocytogenes comprising hypervirulent isolates
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
ethz.journal.title
Nature Communications
ethz.journal.volume
10
en_US
ethz.journal.issue
1
en_US
ethz.journal.abbreviated
Nat Commun
ethz.pages.start
4283
en_US
ethz.size
16 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
London
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02701 - Inst.f. Lebensmittelwiss.,Ernährung,Ges. / Institute of Food, Nutrition, and Health::03651 - Loessner, Martin / Loessner, Martin
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02701 - Inst.f. Lebensmittelwiss.,Ernährung,Ges. / Institute of Food, Nutrition, and Health::03651 - Loessner, Martin / Loessner, Martin
ethz.date.deposited
2019-10-08T02:41:34Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2019-10-08T07:37:15Z
ethz.rosetta.lastUpdated
2024-02-02T09:31:36Z
ethz.rosetta.versionExported
true
ethz.COinS
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