Loss of PTPN22 abrogates the beneficial effect of cohousing-mediated fecal microbiota transfer in murine colitis

Open access
Date
2019-09-09Type
- Journal Article
Citations
Cited 12 times in
Web of Science
Cited 13 times in
Scopus
ETH Bibliography
yes
Altmetrics
Abstract
Fecal microbiota transfer (FMT) is a very efficient approach for the treatment of severe and recurring C. difficile infections. However, the beneficial effect of FMT in other disorders such as ulcerative colitis (UC) or Crohn’s disease remains unclear. Furthermore, it is currently unknown how disease-associated genetic variants in donors or recipients influence the effect of FMT. We found that bacteria-transfer from wild-type (WT) donors via cohousing was efficient in inducing recovery from colitis in WT mice, but not in mice deficient in protein-tyrosine phosphatase non-receptor type 22 (PTPN22), a known risk gene for several chronic inflammatory diseases. Also cohousing of PTPN22-deficient mice with diseased WT mice failed to induce faster recovery. Our data indicate that the genetic background of the donor and the recipient influences the outcome of microbiota transfer, and offers a potential explanation why transfer of fecal microbes from some, but not all donors is efficient in UC patients. Show more
Permanent link
https://doi.org/10.3929/ethz-b-000369442Publication status
publishedExternal links
Journal / series
Mucosal ImmunologyVolume
Pages / Article No.
Publisher
Nature Publishing GroupOrganisational unit
03626 - Lacroix, Christophe / Lacroix, Christophe
Funding
154488 - The Microbe-Host Interface: Molecular Mechanisms Mediating Protective and Pathological Innate and Adaptive Immune Responses within the Gut (SNF)
More
Show all metadata
Citations
Cited 12 times in
Web of Science
Cited 13 times in
Scopus
ETH Bibliography
yes
Altmetrics