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dc.contributor.author
Spalinger, Marianne R.
dc.contributor.author
Schwarzfischer, Marlene
dc.contributor.author
Hering, Larissa
dc.contributor.author
Shawki, Ali
dc.contributor.author
Sayoc, Anica
dc.contributor.author
Santos, Alina
dc.contributor.author
Gottier, Claudia
dc.contributor.author
Lang, Silvia
dc.contributor.author
Bäbler, Katharina
dc.contributor.author
Geirnaert, Annelies
dc.contributor.author
Lacroix, Christophe
dc.contributor.author
Leventhal, Gabriel E.
dc.contributor.author
Dai, Xuezhi
dc.contributor.author
Rawlings, David
dc.contributor.author
Chan, Andrew A.
dc.contributor.author
Rogler, Gerhard
dc.contributor.author
McCole, Declan F.
dc.contributor.author
Scharl, Michael
dc.date.accessioned
2019-11-11T16:17:16Z
dc.date.available
2019-10-09T09:42:34Z
dc.date.available
2019-10-11T10:35:55Z
dc.date.available
2019-11-11T16:17:16Z
dc.date.issued
2019-09-09
dc.identifier.issn
1933-0219
dc.identifier.issn
1935-3456
dc.identifier.other
10.1038/s41385-019-0201-1
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/369442
dc.identifier.doi
10.3929/ethz-b-000369442
dc.description.abstract
Fecal microbiota transfer (FMT) is a very efficient approach for the treatment of severe and recurring C. difficile infections. However, the beneficial effect of FMT in other disorders such as ulcerative colitis (UC) or Crohn’s disease remains unclear. Furthermore, it is currently unknown how disease-associated genetic variants in donors or recipients influence the effect of FMT. We found that bacteria-transfer from wild-type (WT) donors via cohousing was efficient in inducing recovery from colitis in WT mice, but not in mice deficient in protein-tyrosine phosphatase non-receptor type 22 (PTPN22), a known risk gene for several chronic inflammatory diseases. Also cohousing of PTPN22-deficient mice with diseased WT mice failed to induce faster recovery. Our data indicate that the genetic background of the donor and the recipient influences the outcome of microbiota transfer, and offers a potential explanation why transfer of fecal microbes from some, but not all donors is efficient in UC patients.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Nature
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
Loss of PTPN22 abrogates the beneficial effect of cohousing-mediated fecal microbiota transfer in murine colitis
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
ethz.journal.title
Mucosal Immunology
ethz.journal.volume
12
en_US
ethz.journal.issue
6
en_US
ethz.journal.abbreviated
Mucosal Immunol
ethz.pages.start
1336
en_US
ethz.pages.end
1347
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.grant
The Microbe-Host Interface: Molecular Mechanisms Mediating Protective and Pathological Innate and Adaptive Immune Responses within the Gut
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
London
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02701 - Inst.f. Lebensmittelwiss.,Ernährung,Ges. / Institute of Food, Nutrition, and Health::03626 - Lacroix, Christophe (emeritus) / Lacroix, Christophe (emeritus)
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02701 - Inst.f. Lebensmittelwiss.,Ernährung,Ges. / Institute of Food, Nutrition, and Health::03626 - Lacroix, Christophe (emeritus) / Lacroix, Christophe (emeritus)
en_US
ethz.grant.agreementno
154488
ethz.grant.agreementno
154488
ethz.grant.fundername
SNF
ethz.grant.fundername
SNF
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.program
Projektförderung in Biologie und Medizin (Abteilung III)
ethz.date.deposited
2019-10-09T09:42:43Z
ethz.source
FORM
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2020-02-15T22:29:45Z
ethz.rosetta.lastUpdated
2024-02-02T09:48:17Z
ethz.rosetta.versionExported
true
ethz.COinS
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