Ward, Thomas R.
- Review Article
Residing at the interface of chemistry and biotechnology, artificial metalloenzymes offer an attractive technology to combine the versatile reaction repertoire of transition metal catalysts with the exquisite catalytic features of enzymes. While earlier efforts in this field predominantly comprised studies in well-defined test-tube environments, a trend towards exploitation of artificial metalloenzymes in more complex environments has recently emerged. This includes the integration of these artificial biocatalysts in enzymatic cascades and reaches out to their utilization in whole cell biotransformations and in vivo, opening up entirely novel prospects for both preparative chemistry and synthetic biology. Here we highlight selected recent developments with a particular focus on challenges and opportunities for the in vivo application of artificial metalloenzymes. Show more
Journal / seriesTrends in Biotechnology
Pages / Article No.
PublisherCell Press; Elsevier
Subjectartificial metalloenzymes; synthetic biology; biocatalysis; directed evolution; xenobiology
Organisational unit03602 - Panke, Sven / Panke, Sven
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