Compartmentalized DNA repair: Rif1 S-acylation links DNA double-strand break repair to the nuclear membrane
- Journal Article
DNA double-strand breaks (DSBs) disrupt the structural integrity of chromosomes. Proper DSB repair pathway choice is critical to avoid the type of gross chromosomal rearrangements that characterize cancer cells. Recent findings reveal S-fatty acylation and membrane anchorage of Rap1-interacting factor 1 (Rif1) as a mechanism providing spatial control over DSB repair pathway choice. Show more
Journal / seriesMolecular and Cellular Oncology
Pages / Article No.
PublisherTaylor & Francis
SubjectNHEJ; HR; Chromosome stability; Protein palmitoylation; DHHC palmitoyl transferases; Pfa4
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