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dc.contributor.author
Douglas, Rodney J.
dc.contributor.author
Martin, Kevan A.C.
dc.date.accessioned
2020-12-20T15:34:30Z
dc.date.available
2017-06-09T12:01:11Z
dc.date.available
2020-12-20T15:34:30Z
dc.date.issued
2011-09
dc.identifier.other
10.1007/s12021-011-9106-1
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/37624
dc.identifier.doi
10.3929/ethz-b-000037624
dc.description.abstract
In 1873 Camillo Golgi discovered his eponymous stain, which he called la reazione nera. By adding to it the concepts of the Neuron Doctrine and the Law of Dynamic Polarisation, Santiago Ramon y Cajal was able to link the individual Golgi-stained neurons he saw down his microscope into circuits. This was revolutionary and we have all followed Cajal’s winning strategy for over a century. We are now on the verge of a new revolution, which offers the prize of a far more comprehensive description of neural circuits and their operation. The hope is that we will exploit the power of computer vision algorithms and modern molecular biological techniques to acquire rapidly reconstructions of single neurons and synaptic circuits, and to control the function of selected types of neurons. Only one item is now conspicuous by its absence: the 21st century equivalent of the concepts of the Neuron Doctrine and the Law of Dynamic Polarisation. Without their equivalent we will inevitably struggle to make sense of our 21st century observations within the 19th and 20th century conceptual framework we have inherited.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Humana Press
en_US
dc.rights.uri
http://rightsstatements.org/page/InC-NC/1.0/
dc.subject
Neuron Doctrine
en_US
dc.subject
Law of Dynamic Polarisation
en_US
dc.subject
Golgi stain
en_US
dc.subject
Canonical cortical circuits
en_US
dc.subject
High-throughput circuit reconstruction
en_US
dc.title
What’s Black and White About the Grey Matter?
en_US
dc.type
Review Article
dc.rights.license
In Copyright - Non-Commercial Use Permitted
dc.date.published
2011-02-18
ethz.journal.title
Neuroinformatics
ethz.journal.volume
9
en_US
ethz.journal.issue
2-3
en_US
ethz.pages.start
167
en_US
ethz.pages.end
179
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.notes
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher
en_US
ethz.identifier.wos
ethz.identifier.nebis
004573511
ethz.publication.place
Totowa, NJ
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
03453 - Douglas, Rodney J.
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich, direkt::00012 - Lehre und Forschung, direkt::00007 - Departemente, direkt::02140 - Departement Informationstechnologie und Elektrotechnik / Department of Information Technology and Electrical Engineering::02533 - Institut für Neuroinformatik (INI) / Institute of Neuroinformatics (INI)::03454 - Martin, Kevan A.C.
en_US
ethz.leitzahl.certified
03453 - Douglas, Rodney J.
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich, direkt::00012 - Lehre und Forschung, direkt::00007 - Departemente, direkt::02140 - Departement Informationstechnologie und Elektrotechnik / Department of Information Technology and Electrical Engineering::02533 - Institut für Neuroinformatik (INI) / Institute of Neuroinformatics (INI)::03454 - Martin, Kevan A.C.
ethz.date.deposited
2017-06-09T12:01:38Z
ethz.source
ECIT
ethz.identifier.importid
imp59364e3e05cdc19819
ethz.ecitpid
pub:60146
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-19T08:28:36Z
ethz.rosetta.lastUpdated
2021-02-15T22:44:39Z
ethz.rosetta.versionExported
true
ethz.COinS
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