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dc.contributor.author
Rubio, Laura
dc.contributor.author
Pyrgiotakis, Georgios
dc.contributor.author
Beltran-Huarac, Juan
dc.contributor.author
Zhang, Yipei
dc.contributor.author
Gaurav, Joshi
dc.contributor.author
Deloid, Glen M.
dc.contributor.author
Spyrogianni, Anastasia
dc.contributor.author
Sarosiek, Kristopher A.
dc.contributor.author
Bello, Dhimiter
dc.contributor.author
Demokritou, Philip
dc.date.accessioned
2020-04-17T12:14:04Z
dc.date.available
2019-11-09T03:40:20Z
dc.date.available
2019-11-11T11:48:13Z
dc.date.available
2020-04-17T12:14:04Z
dc.date.issued
2019-10-29
dc.identifier.issn
1743-8977
dc.identifier.other
10.1186/s12989-019-0325-1
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/376532
dc.identifier.doi
10.3929/ethz-b-000376532
dc.description.abstract
Background Amorphous silica nanoparticles (SiO2 NPs) have been regarded as relatively benign nanomaterials, however, this widely held opinion has been questioned in recent years by several reports on in vitro and in vivo toxicity. Surface chemistry, more specifically the surface silanol content, has been identified as an important toxicity modulator for SiO2 NPs. Here, quantitative relationships between the silanol content on SiO2 NPs, free radical generation and toxicity have been identified, with the purpose of synthesizing safer-by-design fumed silica nanoparticles. Results Consistent and statistically significant trends were seen between the total silanol content, cell membrane damage, and cell viability, but not with intracellular reactive oxygen species (ROS), in the macrophages RAW264.7. SiO2 NPs with lower total silanol content exhibited larger adverse cellular effects. The SAEC epithelial cell line did not show any sign of toxicity by any of the nanoparticles. Free radical generation and surface reactivity of these nanoparticles were also influenced by the temperature of combustion and total silanol content. Conclusion Surface silanol content plays an important role in cellular toxicity and surface reactivity, although it might not be the sole factor influencing fumed silica NP toxicity. It was demonstrated that synthesis conditions for SiO2 NPs influence the type and quantity of free radicals, oxidative stress, nanoparticle interaction with the biological milieu they come in contact with, and determine the specific mechanisms of toxicity. We demonstrate here that it is possible to produce much less toxic fumed silicas by modulating the synthesis conditions.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
BioMed Central
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Silanol groups
en_US
dc.subject
Amorphous silica
en_US
dc.subject
Surface reactivity
en_US
dc.subject
Flame spray pyrolysis
en_US
dc.subject
Toxicity
en_US
dc.title
Safer-by-design flame-sprayed silicon dioxide nanoparticles: the role of silanol content on ROS generation, surface activity and cytotoxicity
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2019-10-29
ethz.journal.title
Particle and Fibre Toxicology
ethz.journal.volume
16
en_US
ethz.journal.issue
1
en_US
ethz.journal.abbreviated
Part Fibre Toxicol
ethz.pages.start
40
en_US
ethz.size
15 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
London
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2019-11-09T03:40:27Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2020-02-15T22:28:32Z
ethz.rosetta.lastUpdated
2021-02-15T10:19:46Z
ethz.rosetta.versionExported
true
ethz.COinS
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