Show simple item record

dc.contributor.author
Stopka, Anna
dc.contributor.author
Meer, Marco
dc.contributor.author
Iber, Dagmar
dc.date.accessioned
2020-12-16T10:42:09Z
dc.date.available
2019-11-12T05:14:53Z
dc.date.available
2019-11-12T08:11:24Z
dc.date.available
2019-11-12T09:02:01Z
dc.date.available
2020-02-12T08:40:48Z
dc.date.available
2020-12-16T10:42:09Z
dc.date.issued
2019-12-12
dc.identifier.issn
1478-3975
dc.identifier.issn
1478-3967
dc.identifier.other
10.1088/1478-3975/ab5613
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/376937
dc.identifier.doi
10.3929/ethz-b-000376937
dc.description.abstract
During morphogenesis, epithelial tubes elongate. in the case of the mammalian lung, biased elongation has been linked to a bias in cell shape and cell division, but it has remained unclear whether a bias in cell shape along the axis of outgrowth is sufficient for biased outgrowth and how it arises. Here, we use our 2D cell-based tissue simulation software $\mathtt{ LBIBCell }$ to investigate the conditions for biased epithelial outgrowth. We show that the observed bias in cell shape and cell division can result in the observed bias in outgrowth only in the case of strong cortical tension, and comparison to biological data suggests that the cortical tension in epithelia is likely sufficient. We explore mechanisms that may result in the observed bias in cell division and cell shapes. To this end, we test the possibility that the surrounding tissue or extracellular matrix acts as a mechanical constraint that biases growth in the longitudinal direction. While external compressive forces can result in the observed bias in outgrowth, we find that they do not result in the observed bias in cell shapes. We conclude that other mechanisms must exist that generate the bias in lung epithelial outgrowth.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
IOP Publishing
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc-nd/3.0/
dc.title
Cell-based simulations of biased epithelial lung growth
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported
dc.date.published
2019-11-11
ethz.journal.title
Physical Biology
ethz.journal.volume
17
en_US
ethz.journal.issue
1
en_US
ethz.pages.start
016006
en_US
ethz.size
19 p.
en_US
ethz.version.deposit
acceptedVersion
en_US
ethz.grant
A 3D Cell-Based Simulation Framework for Morphogenetic Problems
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Bristol
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02060 - Dep. Biosysteme / Dep. of Biosystems Science and Eng.::03791 - Iber, Dagmar / Iber, Dagmar
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02060 - Dep. Biosysteme / Dep. of Biosystems Science and Eng.::03791 - Iber, Dagmar / Iber, Dagmar
en_US
ethz.grant.agreementno
170930
ethz.grant.fundername
SNF
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.program
Interdisziplinäres Projekt
ethz.date.deposited
2019-11-12T05:15:03Z
ethz.source
FORM
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.date.embargoend
2020-12-12
ethz.rosetta.installDate
2020-02-12T08:41:00Z
ethz.rosetta.lastUpdated
2022-03-29T04:35:55Z
ethz.rosetta.versionExported
true
ethz.COinS
ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.atitle=Cell-based%20simulations%20of%20biased%20epithelial%20lung%20growth&rft.jtitle=Physical%20Biology&rft.date=2019-12-12&rft.volume=17&rft.issue=1&rft.spage=016006&rft.issn=1478-3975&1478-3967&rft.au=Stopka,%20Anna&Meer,%20Marco&Iber,%20Dagmar&rft.genre=article&rft_id=info:doi/10.1088/1478-3975/ab5613&
 Search print copy at ETH Library

Files in this item

Thumbnail

Publication type

Show simple item record