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dc.contributor.author
Ma, Qiaoli
dc.contributor.author
Decker, Yann
dc.contributor.author
Müller, Andreas
dc.contributor.author
Ineichen, Benjamin V.
dc.contributor.author
Proulx, Steven T.
dc.date.accessioned
2020-01-27T15:30:52Z
dc.date.available
2019-11-14T03:41:12Z
dc.date.available
2019-11-14T09:13:40Z
dc.date.available
2020-01-27T15:30:52Z
dc.date.issued
2019-11-04
dc.identifier.issn
0022-1007
dc.identifier.issn
1540-0069
dc.identifier.issn
1540-9538
dc.identifier.other
10.1084/jem.20190351
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/377532
dc.identifier.doi
10.3929/ethz-b-000377532
dc.description.abstract
The pathways of circulation and clearance of cerebrospinal fluid (CSF) in the spine have yet to be elucidated. We have recently shown with dynamic in vivo imaging that routes of outflow of CSF in mice occur along cranial nerves to extracranial lymphatic vessels. Here, we use near-infrared and magnetic resonance imaging to demonstrate the flow of CSF tracers within the spinal column and reveal the major spinal pathways for outflow to lymphatic vessels in mice. We found that after intraventricular injection, a spread of CSF tracers occurs within both the central canal and the spinal subarachnoid space toward the caudal end of the spine. Outflow of CSF tracers from the spinal subarachnoid space occurred predominantly from intravertebral regions of the sacral spine to lymphatic vessels, leading to sacral and iliac LNs. Clearance of CSF from the spine to lymphatic vessels may have significance for many conditions, including multiple sclerosis and spinal cord injury.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Rockefeller University Press
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc-sa/4.0/
dc.title
Clearance of cerebrospinal fluid from the sacral spine through lymphatic vessels
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International
dc.date.published
2019-08-27
ethz.journal.title
Journal of Experimental Medicine
ethz.journal.volume
216
en_US
ethz.journal.issue
11
en_US
ethz.journal.abbreviated
J Exp Med
ethz.pages.start
2492
en_US
ethz.pages.end
2502
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
New York, NY
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2019-11-14T03:41:20Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2019-11-14T09:13:58Z
ethz.rosetta.lastUpdated
2020-01-27T15:31:03Z
ethz.rosetta.versionExported
true
ethz.COinS
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