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dc.contributor.author
Trachsel, Lucca
dc.contributor.author
Johnbosco, Castro
dc.contributor.author
Lang, Thamar
dc.contributor.author
Benetti, Edmond M.
dc.contributor.author
Zenobi-Wong, Marcy
dc.date.accessioned
2020-04-17T05:48:11Z
dc.date.available
2019-11-29T12:31:04Z
dc.date.available
2019-11-29T12:41:28Z
dc.date.available
2020-04-17T05:48:11Z
dc.date.issued
2019-12-09
dc.identifier.other
10.1021/acs.biomac.9b01266
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/381607
dc.identifier.doi
10.3929/ethz-b-000381607
dc.description.abstract
Double-network (DN) hydrogels are fabricated from poly(2-ethyl-2-oxazoline) (PEOXA)–peptide conjugates, which can be enzymatically crosslinked in the presence of Sortase A (SA), and physical networks of alginate (Alg), yielding matrices with improved mechanical properties with respect to the corresponding PEOXA and Alg single networks and excellent cell viability of encapsulated human auricular chondrocytes (hACs). The addition of a low content of cellulose nanofibrils (CNFs) within DN hydrogel formulations provides the rheological properties needed for extrusion-based three-dimensional (3D) printing, generating constructs with a good shape fidelity. In the presence of hACs, PEOXA–Alg–CNF prehydrogel mixtures can be bioprinted, finally generating 3D-structured DN hydrogel supports showing a cell viability of more than 90%. Expanding the application of poly(2-alkyl-2-oxazoline)-based formulations in the design of tissue-engineering constructs, this study further demonstrates how SA-mediated enzymatic crosslinking represents a suitable and fully orthogonal method to generate biocompatible hydrogels with fast kinetics.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
ACS Publications
en_US
dc.title
Double-Network Hydrogels Including Enzymatically Crosslinked Poly-(2-alkyl-2-oxazoline)s for 3D Bioprinting of Cartilage-Engineering Constructs.
en_US
dc.type
Journal Article
dc.date.published
2019-11-12
ethz.journal.title
Biomacromolecules
ethz.journal.volume
20
en_US
ethz.journal.issue
12
en_US
ethz.pages.start
4502
en_US
ethz.pages.end
4511
en_US
ethz.size
10 p.; 35 p. accepted version; 5 p. supporting information
en_US
ethz.version.deposit
acceptedVersion
en_US
ethz.grant
Chondrogenic Bioinks for Bioprinting Stable Cartilage Grafts
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Washington, DC
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02518 - Institut für Biomechanik / Institute for Biomechanics::03949 - Zenobi-Wong, Marcy / Zenobi-Wong, Marcy
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02518 - Institut für Biomechanik / Institute for Biomechanics::03949 - Zenobi-Wong, Marcy / Zenobi-Wong, Marcy
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02518 - Institut für Biomechanik / Institute for Biomechanics::03949 - Zenobi-Wong, Marcy / Zenobi-Wong, Marcy
ethz.grant.agreementno
166052
ethz.grant.fundername
SNF
ethz.grant.funderDoi
10.13039/501100001711
ethz.relation.isDerivedFrom
10.3929/ethz-b-000362642
ethz.date.deposited
2019-11-29T12:31:12Z
ethz.source
FORM
ethz.eth
yes
en_US
ethz.availability
Embargoed
en_US
ethz.date.embargoend
2020-11-29
ethz.rosetta.installDate
2019-11-29T12:41:45Z
ethz.rosetta.lastUpdated
2020-04-17T05:48:23Z
ethz.rosetta.versionExported
true
ethz.COinS
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