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dc.contributor.author
Paganini, Daniela
dc.contributor.author
Uyoga, Mary A.
dc.contributor.author
Kortman, Guus A.M.
dc.contributor.author
Boekhorst, Jos
dc.contributor.author
Schneeberger, Sacha
dc.contributor.author
Karanja, Simon
dc.contributor.author
Hennet, Thierry
dc.contributor.author
Zimmermann, Michael B.
dc.date.accessioned
2019-12-06T12:26:55Z
dc.date.available
2019-12-06T11:07:05Z
dc.date.available
2019-12-06T12:26:55Z
dc.date.issued
2019-11
dc.identifier.other
10.3390/nu11112596
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/383357
dc.identifier.doi
10.3929/ethz-b-000383357
dc.description.abstract
There is little data on human milk oligosaccharide (HMO) composition in Sub-Saharan Africa. Iron fortificants adversely affect the infant gut microbiota, while co-provision of prebiotic galacto-oligosaccharides (GOS) mitigates most of the adverse effects. Whether variations in maternal HMO profile can influence the infant response to iron and/or GOS fortificants is unknown. The aim of this study was to determine HMO profiles and the secretor/non-secretor phenotype of lactating Kenyan mothers and investigate their effects on the maternal and infant gut microbiota, and on the infant response to a fortification intervention with 5 mg iron (2.5 mg as sodium iron ethylenediaminetetraacetate and 2.5 mg as ferrous fumarate) and 7.5 g GOS. We studied mother–infant pairs (n = 80) participating in a 4-month intervention trial in which the infants (aged 6.5–9.5 months) received daily a micronutrient powder without iron, with iron or with iron and GOS. We assessed: (1) maternal secretor status and HMO composition; (2) effects of secretor status on the maternal and infant gut microbiota in a cross-sectional analysis at baseline of the intervention trial; and (3) interactions between secretor status and intervention groups during the intervention trial on the infant gut microbiota, gut inflammation, iron status, growth and infectious morbidity. Secretor prevalence was 72% and HMOs differed between secretors and non-secretors and over time of lactation. Secretor status did not predict the baseline composition of the maternal and infant gut microbiota. There was a secretor-status-by-intervention-group interaction on Bifidobacterium (p = 0.021), Z-scores for length-for-age (p = 0.022) and weight-for-age (p = 0.018), and soluble transferrin receptor (p = 0.041). In the no iron group, longitudinal prevalence of diarrhea was higher among infants of non-secretors (23.8%) than of secretors (10.4%) (p = 0.001). In conclusion, HMO profile may modulate the infant gut microbiota response to fortificant iron; compared to infants of secretor mothers, infants of non-secretor mothers may be more vulnerable to the adverse effect of iron but also benefit more from the co-provision of GOS.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
MDPI
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Human milk oligosaccharides
en_US
dc.subject
Infant
en_US
dc.subject
Iron
en_US
dc.subject
Africa
en_US
dc.subject
Kenya
en_US
dc.subject
Prebiotic
en_US
dc.subject
Galacto-oligosaccharides
en_US
dc.subject
Gut microbiota
en_US
dc.subject
Secretor
en_US
dc.subject
Micronutrient powder
en_US
dc.title
Maternal Human Milk Oligosaccharide Profile Modulates the Impact of an Intervention with Iron and Galacto-Oligosaccharides in Kenyan Infants
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
ethz.journal.title
Nutrients
ethz.journal.volume
11
en_US
ethz.journal.issue
11
en_US
ethz.pages.start
2596
en_US
ethz.size
17 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.publication.place
Basel
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02701 - Inst.f. Lebensmittelwiss.,Ernährung,Ges. / Institute of Food, Nutrition, and Health::03957 - Zimmermann, Michael Bruce / Zimmermann, Michael Bruce
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02701 - Inst.f. Lebensmittelwiss.,Ernährung,Ges. / Institute of Food, Nutrition, and Health::03957 - Zimmermann, Michael Bruce / Zimmermann, Michael Bruce
en_US
ethz.date.deposited
2019-12-06T11:07:14Z
ethz.source
FORM
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2019-12-06T12:27:08Z
ethz.rosetta.lastUpdated
2021-02-15T06:58:59Z
ethz.rosetta.versionExported
true
ethz.COinS
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