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dc.contributor.author
Balakirev, Evgeniy S.
dc.contributor.author
Anisimova, Maria
dc.contributor.author
Ayala, Francisco J.
dc.date.accessioned
2018-09-20T11:44:37Z
dc.date.available
2017-06-09T13:15:28Z
dc.date.available
2018-09-20T11:44:37Z
dc.date.issued
2011-07-22
dc.identifier.issn
1932-6203
dc.identifier.other
10.1371/journal.pone.0022613
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/38629
dc.identifier.doi
10.3929/ethz-b-000038629
dc.description.abstract
Tandemly arranged paralogous genes lbe and lbl are members of the Drosophila NK homeobox family. We analyzed population samples of Drosophila melanogaster from Africa, Europe, North and South America, and single strains of D. sechellia, D. simulans, and D. yakuba within two linked regions encompassing partial sequences of lbe and lbl. The evolution of lbe and lbl is highly constrained due to their important regulatory functions. Despite this, a variety of forces have shaped the patterns of variation in lb genes: recombination, intragenic gene conversion and natural selection strongly influence background variation created by linkage disequilibrium and dimorphic haplotype structure. The two genes exhibited similar levels of nucleotide diversity and positive selection was detected in the noncoding regions of both genes. However, synonymous variability was significantly higher for lbe: no nonsynonymous changes were observed in this gene. We argue that balancing selection impacts some synonymous sites of the lbe gene. Stability of mRNA secondary structure was significantly different between the lbe (but not lbl) haplotype groups and may represent a driving force of balancing selection in epistatically interacting synonymous sites. Balancing selection on synonymous sites may be the first, or one of a few such observations, in Drosophila. In contrast, recurrent positive selection on lbl at the protein level influenced evolution at three codon sites. Transcription factor binding-site profiles were different for lbe and lbl, suggesting that their developmental functions are not redundant. Combined with our previous results on nucleotide variation in esterase and other homeobox genes, these results suggest that interplay of balancing and directional selection may be a general feature of molecular evolution in Drosophila and other eukaryote genomes.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Public Library of Science
en_US
dc.rights.uri
http://creativecommons.org/publicdomain/zero/1.0/
dc.title
Complex Interplay of Evolutionary Forces in the ladybird Homeobox Genes of Drosophila melanogaster
en_US
dc.type
Journal Article
dc.rights.license
CC0 1.0 Universal
ethz.journal.title
PLoS ONE
ethz.journal.volume
6
en_US
ethz.journal.issue
7
en_US
ethz.journal.abbreviated
PLoS ONE
ethz.pages.start
e22613
en_US
ethz.size
12 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.nebis
006206116
ethz.publication.place
Lawrence, KS, USA
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
03309 - Gonnet, Gaston
en_US
ethz.leitzahl.certified
03309 - Gonnet, Gaston
ethz.date.deposited
2017-06-09T13:15:49Z
ethz.source
ECIT
ethz.identifier.importid
imp59364e51ecc0c81912
ethz.ecitpid
pub:62286
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-19T09:50:45Z
ethz.rosetta.lastUpdated
2021-02-15T01:49:43Z
ethz.rosetta.versionExported
true
ethz.COinS
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