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dc.contributor.author
Stoiber, Lukas
dc.contributor.author
Ghorbani, Niky
dc.contributor.author
Kelm, Marcus
dc.contributor.author
Kuehne, Titus
dc.contributor.author
Rank, Nina
dc.contributor.author
Lapinskas, Tomas
dc.contributor.author
Stehning, Christian
dc.contributor.author
Pieske, Burkert
dc.contributor.author
Falk, Volkmar
dc.contributor.author
Gebker, Rolf
dc.contributor.author
Kelle, Sebastian
dc.date.accessioned
2020-03-30T07:11:27Z
dc.date.available
2020-01-13T14:53:28Z
dc.date.available
2020-01-14T07:47:37Z
dc.date.available
2020-03-30T07:09:37Z
dc.date.available
2020-03-30T07:11:27Z
dc.date.issued
2020-04
dc.identifier.other
10.1007/s00392-019-01525-8
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/389861
dc.identifier.doi
10.3929/ethz-b-000389861
dc.description.abstract
Objective Aortic distensibility (AD) represents a well-established parameter of aortic stiffness. It remains unclear, however, whether AD can be obtained with high reproducibility in standard 4-chamber cine CMR images of the descending aorta. This study investigated the intra- and inter-observer agreement of AD based on different angles of the aorta and provided a sample size calculation of AD for future trials. Methods Thirty-one patients underwent CMR. Angulation of the descending aorta was performed to obtain strictly transversal and orthogonal cross-sectional aortic areas. AD was obtained both area and diameter based. Results For area-based values, inter-observer agreement was highest for 4-chamber AD (ICC 0.97; 95% CI 0.93–99), followed by orthogonal AD (ICC 0.96; 95% CI 0.91–98) and transversal AD (ICC 0.93; 95% CI 0.80–97). For diameter-based values, agreement was also highest for 4-chamber AD (ICC 0.97; 95% CI 0.94–99), followed by orthogonal AD (ICC 0.96; 95% CI 0.92–98) and transversal AD (ICC 0.91; 95% CI 0.77–96). Bland–Altman plots confirmed a small variation among observers. Sample size calculation showed a sample size of 12 patients to detect a change in 4-chamber AD of 1 × 10−3 mmHg−1 with either the area or diameter approach. Conclusion AD measurements are highly reproducible and allow an accurate and rapid assessment of arterial compliance from standard 4-chamber cine CMR.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Springer
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Aortic distensibility
en_US
dc.subject
Compliance
en_US
dc.subject
Cardiac magnetic resonance imaging
en_US
dc.subject
Cine MRI
en_US
dc.subject
Reproducibility
en_US
dc.title
Validation of simple measures of aortic distensibility based on standard 4-chamber cine CMR: a new approach for clinical studies
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2019-07-13
ethz.journal.title
Clinical Research in Cardiology
ethz.journal.volume
109
en_US
ethz.journal.issue
4
en_US
ethz.pages.start
454
en_US
ethz.pages.end
464
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.scopus
ethz.publication.place
Heidelberg
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02540 - Institut für Translationale Medizin / Institute of Translational Medicine::09667 - Falk, Volkmar / Falk, Volkmar
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02540 - Institut für Translationale Medizin / Institute of Translational Medicine::09667 - Falk, Volkmar / Falk, Volkmar
en_US
ethz.identifier.orcidWorkCode
66892742
ethz.date.deposited
2020-01-13T14:53:38Z
ethz.source
FORM
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2020-03-30T07:09:48Z
ethz.rosetta.lastUpdated
2022-03-29T01:40:05Z
ethz.rosetta.versionExported
true
ethz.COinS
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